TDZD-8 (CHEBI:147411)

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ChEBI Name	TDZD-8

ChEBI ID	CHEBI:147411

Definition	A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3β (GSK3β). An experimental compound which was being developed for the potential treatment of Alzheimer's disease.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Kalpana P

Supplier Information

Download	Molfile XML SDF

Formula

C10H10N2O2S

Net Charge

Average Mass

222.260

Monoisotopic Mass

222.04630

InChI

InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

InChIKey

JDSJDASOXWCHPN-UHFFFAOYSA-N

SMILES

N1(C(N(C(S1)=O)CC=2C=CC=CC2)=O)C

Roles Classification
Biological Role(s):	EC 2.7.11.26 (tau-protein kinase) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of tau-protein kinase inhibitor (EC 2.7.11.26). apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. anti-inflammatory agent Any compound that has anti-inflammatory effects.

ChEBI Ontology
Outgoing	TDZD-8 (CHEBI:147411) has role anti-inflammatory agent (CHEBI:67079) TDZD-8 (CHEBI:147411) has role antineoplastic agent (CHEBI:35610) TDZD-8 (CHEBI:147411) has role apoptosis inducer (CHEBI:68495) TDZD-8 (CHEBI:147411) has role EC 2.7.11.26 (tau-protein kinase) inhibitor (CHEBI:91092) TDZD-8 (CHEBI:147411) has role neuroprotective agent (CHEBI:63726) TDZD-8 (CHEBI:147411) is a benzenes (CHEBI:22712) TDZD-8 (CHEBI:147411) is a thiadiazolidine (CHEBI:48865)

IUPAC Name

4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Registry Number	Type	Source
327036-89-5	CAS Registry Number	SUBMITTER

Last Modified

07 April 2020