CHEBI:71253 - asenapine

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ChEBI Name asenapine
ChEBI ID CHEBI:71253
Definition A racemate consisting of equal amounts of (R,R)- and (S,S)-asenapine. Used as its maleate salt for the acute treatment of schizophrenia and acute treatment of manic or mixed episodes associated with bipolar I disorder with or without psychotic features.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Biological Role(s): alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Application(s): alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
psychotropic drug
A loosely defined grouping of drugs that have effects on psychological function.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
second generation antipsychotic
Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing asenapine (CHEBI:71253) has part (R,R)-asenapine (CHEBI:71256)
asenapine (CHEBI:71253) has part (S,S)-asenapine (CHEBI:71257)
asenapine (CHEBI:71253) has role α-adrenergic antagonist (CHEBI:37890)
asenapine (CHEBI:71253) has role β-adrenergic antagonist (CHEBI:35530)
asenapine (CHEBI:71253) has role dopaminergic antagonist (CHEBI:48561)
asenapine (CHEBI:71253) has role psychotropic drug (CHEBI:35471)
asenapine (CHEBI:71253) has role second generation antipsychotic (CHEBI:65191)
asenapine (CHEBI:71253) has role serotonergic antagonist (CHEBI:48279)
asenapine (CHEBI:71253) is a racemate (CHEBI:60911)
asenapine (CHEBI:71253) is conjugate base of asenapine(1+) (CHEBI:71249)
Incoming asenapine(1+) (CHEBI:71249) is conjugate acid of asenapine (CHEBI:71253)
IUPAC Name
rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
INNs Sources
asenapina WHO MedNet
asénapine WHO MedNet
asenapine WHO MedNet
asenapinum WHO MedNet
Synonyms Sources
(±)-asenapine ChEBI
(3aRS,12bRS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole ChEBI
trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole ChemIDplus
Manual Xrefs Databases
Asenapine Wikipedia
US2005119248 Patent
US2006084692 Patent
US2006229352 Patent
WO2012038975 Patent
WO2012040845 Patent
WO2012123325 Patent
View more database links
Registry Numbers Types Sources
3654823 Reaxys Registry Number Reaxys
65576-45-6 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
22 February 2017