CHEBI:189866 - PPDA

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name PPDA
ChEBI ID CHEBI:189866
Definition A racemate comprising equimolar amounts of (2R,3S)- and (2S,3R)-PPDA. It is a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (formally NR2C/NR2D) containing receptors.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Stan Laulederkind
Formula C21H18N2O5
Net Charge 0
Average Mass 378.384
Monoisotopic Mass 378.12157
Roles Classification
Biological Role(s): NMDA receptor antagonist
Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing PPDA (CHEBI:189866) has part (2R,3S)-PPDA (CHEBI:189871)
PPDA (CHEBI:189866) has part (2S,3R)-PPDA (CHEBI:189872)
PPDA (CHEBI:189866) has role NMDA receptor antagonist (CHEBI:60643)
PPDA (CHEBI:189866) is a racemate (CHEBI:60911)
IUPAC Name
rac-(2R,3S)-1-(phenanthren-2-ylcarbonyl)piperazine-2,3-dicarboxylic acid
Synonyms Sources
(2S*,3R*)-1-(phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acid ChEBI
cis-1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid ChEBI
cis-PPDA SUBMITTER
Registry Number Type Source
684283-16-7 CAS Registry Number ChEBI
Citations Waiting for Citations Types Sources
14718249 PubMed citation Europe PMC
15743930 PubMed citation Europe PMC
19684252 PubMed citation Europe PMC
20936660 PubMed citation SUBMITTER
21497673 PubMed citation Europe PMC
21651766 PubMed citation Europe PMC
22950043 PubMed citation Europe PMC
29531223 PubMed citation SUBMITTER
31969570 PubMed citation Europe PMC
35057644 PubMed citation Europe PMC
Last Modified
11 May 2022