CHEBI:85995 - lenvatinib mesylate

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name lenvatinib mesylate
ChEBI ID CHEBI:85995
Definition A methanesulfonate salt obtained by reaction of lenvatinib with one molar equivalent of methanesulfonic acid. A multi-kinase inhibitor and orphan drug used (as its mesylate salt) for the treatment of various types of thyroid cancer that do not respond to radioiodine.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
more structures >>
Formula C22H23ClN4O7S
Net Charge 0
Average Mass 522.960
Monoisotopic Mass 522.09760
InChI InChI=1S/C21H19ClN4O4.CH4O3S/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11;1-5(2,3)4/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28);1H3,(H,2,3,4)
InChIKey HWLFIUUAYLEFCT-UHFFFAOYSA-N
SMILES C=1(C(=CC2=C(C1)N=CC=C2OC3=CC(=C(C=C3)NC(NC4CC4)=O)Cl)C(N)=O)OC.S(=O)(=O)(C)O
Roles Classification
Biological Role(s): EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
fibroblast growth factor receptor antagonist
An antagonist at the fibroblast growth factor receptor.
vascular endothelial growth factor receptor antagonist
An antagonist at the vascular endothelial growth factor receptor.
Application(s): orphan drug
Any drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing lenvatinib mesylate (CHEBI:85995) has part lenvatinib(1+) (CHEBI:85998)
lenvatinib mesylate (CHEBI:85995) has role antineoplastic agent (CHEBI:35610)
lenvatinib mesylate (CHEBI:85995) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
lenvatinib mesylate (CHEBI:85995) has role fibroblast growth factor receptor antagonist (CHEBI:63457)
lenvatinib mesylate (CHEBI:85995) has role orphan drug (CHEBI:71031)
lenvatinib mesylate (CHEBI:85995) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
lenvatinib mesylate (CHEBI:85995) is a methanesulfonate salt (CHEBI:38037)
IUPAC Names
6-carbamoyl-4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinolin-1-ium methanesulfonate
methanesulfonic acid—4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide (1/1)
Synonyms Sources
E7080 ChemIDplus
Lenvatinib mesilate KEGG DRUG
N-(4-((6-Carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)-N'-cyclopropylurea monomethanesulfonate ChemIDplus
UNII-3J78384F61 ChemIDplus
Brand Names Sources
Lenvima ChEBI
Lenvima KEGG DRUG
Manual Xref Database
D09920 KEGG DRUG
View more database links
Registry Numbers Types Sources
14616854 Reaxys Registry Number Reaxys
857890-39-2 CAS Registry Number KEGG DRUG
857890-39-2 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
24190702 PubMed citation Europe PMC
24548978 PubMed citation Europe PMC
24658627 PubMed citation Europe PMC
24815456 PubMed citation Europe PMC
25022720 PubMed citation Europe PMC
25295214 PubMed citation Europe PMC
25425971 PubMed citation Europe PMC
25795101 PubMed citation Europe PMC
25798037 PubMed citation Europe PMC
25798040 PubMed citation Europe PMC
25859118 PubMed citation Europe PMC
25913680 PubMed citation Europe PMC
26026266 PubMed citation Europe PMC
Last Modified
20 May 2017