CHEBI:133397 - Ki11502

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ChEBI Name Ki11502
ChEBI ID CHEBI:133397
Definition A member of the class of quinolines that acts as a receptor tyrosine kinase inhibitor and apoptosis inducer with potential for use in treatment of leukemia and colorectal cancer.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter TheOtherDave
Supplier Information
Download Molfile XML SDF
Formula C26H23N3O4S
Net Charge 0
Average Mass 473.546
Monoisotopic Mass 473.14093
InChI InChI=1S/C26H23N3O4S/c1-16-6-4-5-7-19(16)25(30)29-26(34)28-17-8-10-18(11-9-17)33-22-12-13-27-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,28,29,30,34)
InChIKey ZXGIBSBJQLLUEE-UHFFFAOYSA-N
SMILES C=1C=CC(=C(C1)C(=O)NC(=S)NC=2C=CC(=CC2)OC=3C=4C=C(C(=CC4N=CC3)OC)OC)C
Roles Classification
Biological Role(s): EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing Ki11502 (CHEBI:133397) has role antineoplastic agent (CHEBI:35610)
Ki11502 (CHEBI:133397) has role apoptosis inducer (CHEBI:68495)
Ki11502 (CHEBI:133397) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
Ki11502 (CHEBI:133397) is a aromatic ether (CHEBI:35618)
Ki11502 (CHEBI:133397) is a benzamides (CHEBI:22702)
Ki11502 (CHEBI:133397) is a quinolines (CHEBI:26513)
Ki11502 (CHEBI:133397) is a thioureas (CHEBI:51276)
IUPAC Name
N-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-methylbenzamide
Synonyms Sources
N-(4-((6,7-dimethoxy-4-quinoyl)oxy)phenyl)-N'-(2-methylbenzoyl)thiourea SUBMITTER
PDGFR tyrosine kinase inhibitor V SUBMITTER
Registry Numbers Types Sources
10488231 Reaxys Registry Number Reaxys
347155-76-4 CAS Registry Number SUBMITTER
Citations Waiting for Citations Types Sources
18309036 PubMed citation Europe PMC
19818754 PubMed citation Europe PMC
20610572 PubMed citation Europe PMC
22683649 PubMed citation Europe PMC
23900414 PubMed citation Europe PMC
24462709 PubMed citation Europe PMC
Last Modified
03 November 2016