CHEBI:141552 - forasartan

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ChEBI Name forasartan
ChEBI ID CHEBI:141552
Definition A member of the class of pyridines that is pyridine which is substituted at positions 2 and 5 by o-(tetrazol-5-yl)phenyl and (3,5-dibutyl-1,2,4-triazol-1-yl)methyl groups, respectively. It is a nonpeptide antagonist of angiotensin II, type 1 (AT1) receptors, used for the treatment of hypertension.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Bijay
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Formula C23H28N8
Net Charge 0
Average Mass 416.523
Monoisotopic Mass 416.24369
InChI InChI=1S/C23H28N8/c1-3-5-11-21-25-22(12-6-4-2)31(28-21)16-17-13-14-20(24-15-17)18-9-7-8-10-19(18)23-26-29-30-27-23/h7-10,13-15H,3-6,11-12,16H2,1-2H3,(H,26,27,29,30)
InChIKey YONOBYIBNBCDSJ-UHFFFAOYSA-N
SMILES C=1C=CC=C(C1C2=NN=NN2)C=3C=CC(=CN3)CN4N=C(N=C4CCCC)CCCC
Roles Classification
Biological Role(s): angiotensin receptor antagonist
A hormone antagonist that blocks angiotensin receptors.
Application(s): angiotensin receptor antagonist
A hormone antagonist that blocks angiotensin receptors.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
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ChEBI Ontology
Outgoing forasartan (CHEBI:141552) has role angiotensin receptor antagonist (CHEBI:61016)
forasartan (CHEBI:141552) has role antihypertensive agent (CHEBI:35674)
forasartan (CHEBI:141552) is a benzenes (CHEBI:22712)
forasartan (CHEBI:141552) is a pyridines (CHEBI:26421)
forasartan (CHEBI:141552) is a tetrazoles (CHEBI:35689)
forasartan (CHEBI:141552) is a triazoles (CHEBI:35727)
IUPAC Name
5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(1H-tetrazol-5-yl)phenyl]pyridine
INNs Sources
forasartán WHO MedNet
forasartan ChemIDplus
forasartan WHO MedNet
forasartanum WHO MedNet
Synonyms Sources
SC 52458 ChemIDplus
SC-52458 SUBMITTER
Manual Xrefs Databases
D04243 KEGG DRUG
DB01342 DrugBank
Forasartan Wikipedia
HMDB0015434 HMDB
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Registry Numbers Types Sources
145216-43-9 CAS Registry Number ChemIDplus
9361619 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
7505365 PubMed citation Europe PMC
8981065 PubMed citation Europe PMC
9156352 PubMed citation Europe PMC
9194514 PubMed citation Europe PMC
Last Modified
20 September 2018