belinostat (CHEBI:61076)

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ChEBI Name	belinostat

ChEBI ID	CHEBI:61076

Definition	A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Sandra Orchard

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Formula

C15H14N2O4S

Net Charge

Average Mass

318.34800

Monoisotopic Mass

318.06743

InChI

InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+

InChIKey

NCNRHFGMJRPRSK-MDZDMXLPSA-N

SMILES

ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1

Roles Classification
Biological Role(s):	EC 3.5.1.98 (histone deacetylase) inhibitor An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	belinostat (CHEBI:61076) has role antineoplastic agent (CHEBI:35610) belinostat (CHEBI:61076) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115) belinostat (CHEBI:61076) is a hydroxamic acid (CHEBI:24650) belinostat (CHEBI:61076) is a olefinic compound (CHEBI:78840) belinostat (CHEBI:61076) is a sulfonamide (CHEBI:35358)

IUPAC Name

(2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide

INN	Source
belinostat	KEGG DRUG

Synonyms	Sources
(2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]acrylamide	IUPAC
N-Hydroxy-3-(3-(phenylsulfamoyl)phenyl)prop-2-enamide	ChemIDplus
PXD101	SUBMITTER

Last Modified

04 March 2015

General Comment
2011-01-25	Inhibits both class I and class II histone deacetylases. See also http://www.cancer.gov/drugdictionary/?CdrID=454583