CHEBI:51045 - cyclizine hydrochloride

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ChEBI Name cyclizine hydrochloride
ChEBI ID CHEBI:51045
Definition A hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride.
Stars This entity has been manually annotated by the ChEBI Team.
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Formulae C18H22N2.HCl
C18H23ClN2
Net Charge 0
Average Mass 302.84200
Monoisotopic Mass 302.15498
InChI InChI=1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H
InChIKey UKPBEPCQTDRZSE-UHFFFAOYSA-N
SMILES Cl.CN1CCN(CC1)C(c1ccccc1)c1ccccc1
Roles Classification
Biological Role(s): H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
cholinergic antagonist
Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
Application(s): H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
central nervous system depressant
A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
cholinergic antagonist
Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
antiemetic
A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
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ChEBI Ontology
Outgoing cyclizine hydrochloride (CHEBI:51045) has part cyclizine (CHEBI:3994)
cyclizine hydrochloride (CHEBI:51045) has role antiemetic (CHEBI:50919)
cyclizine hydrochloride (CHEBI:51045) has role central nervous system depressant (CHEBI:35488)
cyclizine hydrochloride (CHEBI:51045) has role cholinergic antagonist (CHEBI:48873)
cyclizine hydrochloride (CHEBI:51045) has role H1-receptor antagonist (CHEBI:37955)
cyclizine hydrochloride (CHEBI:51045) is a hydrochloride (CHEBI:36807)
IUPAC Name
1-(diphenylmethyl)-4-methylpiperazine hydrochloride
Synonyms Sources
(±)-1-diphenylmethyl-4-methylpiperazine hydrochloride ChemIDplus
1-(Diphenylmethyl)-4-methylpiperazine monohydrochloride ChemIDplus
Cyclizine HCl ChemIDplus
cyclizine monohydrochloride ChemIDplus
Brand Name Source
Valoid ChEBI
Manual Xrefs Databases
D03622 KEGG DRUG
DB01176 DrugBank
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Registry Numbers Types Sources
303-25-3 CAS Registry Number ChemIDplus
3743457 Beilstein Registry Number Beilstein
Last Modified
20 February 2012
General Comment
2011-01-07 A sedating histamine H1 antagonist with antimuscarinic activity, cyclizine is given by mouth as the hydrochloride salt, or intramuscularly or intravenously as the lactate, for the control of management of postoperative nausea and vomiting, and for the management of motion sickness.