harman (CHEBI:5623)

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ChEBI Name	harman

ChEBI ID	CHEBI:5623

Definition	An indole alkaloid fundamental parent with a structure of 9H-β-carboline carrying a methyl substituent at C-1. It has been isolated from the bark of Sickingia rubra, Symplocus racemosa, Passiflora incarnata, Peganum harmala, Banisteriopsis caapi and Tribulus terrestris, as well as from tobacco smoke. It is a specific, reversible inhibitor of monoamine oxidase A.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C12H10N2

Net Charge

Average Mass

182.22120

Monoisotopic Mass

182.08440

InChI

InChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3

InChIKey

PSFDQSOCUJVVGF-UHFFFAOYSA-N

SMILES

Cc1nccc2c3ccccc3[nH]c12

Metabolite of Species	Details
Symplocos setchuensis (NCBI:txid210366)	Found in stem (BTO:0001300). See: PubMed

Roles Classification
Biological Role(s):	plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. EC 1.4.3.4 (monoamine oxidase) inhibitor An EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of monoamine oxidase (EC 1.4.3.4). anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. (via alkaloid )

ChEBI Ontology
Outgoing	harman (CHEBI:5623) has role anti-HIV agent (CHEBI:64946) harman (CHEBI:5623) has role EC 1.4.3.4 (monoamine oxidase) inhibitor (CHEBI:38623) harman (CHEBI:5623) has role plant metabolite (CHEBI:76924) harman (CHEBI:5623) is a harmala alkaloid (CHEBI:61379) harman (CHEBI:5623) is a indole alkaloid (CHEBI:38958) harman (CHEBI:5623) is a indole alkaloid fundamental parent (CHEBI:38482)

Incoming	harmaline (CHEBI:28172) has parent hydride harman (CHEBI:5623) harmalol (CHEBI:27943) has parent hydride harman (CHEBI:5623) harmine (CHEBI:28121) has parent hydride harman (CHEBI:5623)

IUPAC Name

1-methyl-9H-pyrido[3,4-b]indole

Last Modified

25 February 2016