CBL0137 (CHEBI:138650)

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ChEBI Name	CBL0137

ChEBI ID	CHEBI:138650

Definition	A member of the class of carbazoles that is 9H-carbazole which is substituted by acetyl groups at positions 3 and 6, and by a 2-isopropylethyl group on the nitrogen atom (position 9). It is a modulator of histone chaperone FACT (FAcilitates Chromatin Transcription) - interaction of CBL0137 with the FACT complex results in simultaneous NF-κ β suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation - and shows antitumour effects in animal models of various cancers.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Sabrina Toro

Supplier Information

Download	Molfile XML SDF

Formula

C21H24N2O2

Net Charge

Average Mass

336.428

Monoisotopic Mass

336.18378

InChI

InChI=1S/C21H24N2O2/c1-13(2)22-9-10-23-20-7-5-16(14(3)24)11-18(20)19-12-17(15(4)25)6-8-21(19)23/h5-8,11-13,22H,9-10H2,1-4H3

InChIKey

JKCSODVERGVDLT-UHFFFAOYSA-N

SMILES

C=12C(=CC(=CC1)C(C)=O)C3=C(N2CCNC(C)C)C=CC(=C3)C(C)=O

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	NF-kappaB inhibitor An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA. p53 activator Any activator of tumour protein p53. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	CBL0137 (CHEBI:138650) has role antineoplastic agent (CHEBI:35610) CBL0137 (CHEBI:138650) has role apoptosis inducer (CHEBI:68495) CBL0137 (CHEBI:138650) has role NF-κB inhibitor (CHEBI:73240) CBL0137 (CHEBI:138650) has role p53 activator (CHEBI:77731) CBL0137 (CHEBI:138650) is a aromatic ketone (CHEBI:76224) CBL0137 (CHEBI:138650) is a carbazoles (CHEBI:48513) CBL0137 (CHEBI:138650) is a methyl ketone (CHEBI:51867) CBL0137 (CHEBI:138650) is a secondary amino compound (CHEBI:50995) CBL0137 (CHEBI:138650) is a tertiary amino compound (CHEBI:50996)

IUPAC Name

1,1'-{9-[2-(isopropylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone

Synonyms	Sources
1,1'-{9-[2-(propan-2-ylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone	IUPAC
3,6-diacetyl-9-(2-isopropylethyl)-9H-carbazole	ChEBI
CBL-0137 free base	ChemIDplus
CBLC137	SUBMITTER
Curaxin 137	SUBMITTER
Curaxin-137	ChEBI

Last Modified

12 October 2017