acrivastine (CHEBI:83168)

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ChEBI Name	acrivastine

ChEBI ID	CHEBI:83168

Definition	A member of the class of pyridines that is (pyridin-2-yl)acrylic acid substituted at position 6 by a [(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl group. It is a non-sedating antihistamine used for treatment of hayfever, urticaria, and rhinitis.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Toni Morrison

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Formula

C22H24N2O2

Net Charge

Average Mass

348.43820

Monoisotopic Mass

348.18378

InChI

InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+

InChIKey

PWACSDKDOHSSQD-IUTFFREVSA-N

SMILES

Cc1ccc(cc1)C(=C/CN1CCCC1)\c1cccc(\C=C\C(O)=O)n1

Roles Classification
Chemical Role(s):	Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). (via oxoacid ) Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.

Application(s):	H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.

ChEBI Ontology
Outgoing	acrivastine (CHEBI:83168) has role H₁-receptor antagonist (CHEBI:37955) acrivastine (CHEBI:83168) is a α,β-unsaturated monocarboxylic acid (CHEBI:79020) acrivastine (CHEBI:83168) is a N-alkylpyrrolidine (CHEBI:46775) acrivastine (CHEBI:83168) is a olefinic compound (CHEBI:78840) acrivastine (CHEBI:83168) is a pyridines (CHEBI:26421)

IUPAC Name

(2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}acrylic acid

Synonyms	Sources
(E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid	ChemIDplus
BW 825C	ChemIDplus
BW A825C	ChemIDplus

Last Modified

22 February 2017