CHEBI:66740 - PF 1163A

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ChEBI Name PF 1163A
ChEBI ID CHEBI:66740
Definition A macrolide antibiotic that is 4,10-dimethyl-1-oxa-4-azacyclotridecane-2,5-dione substituted by a 4-(2-hydroxyethoxy)benzyl group at position 3 and a (2R)-2-hydroxypentyl group at position 13 (the 3S,10R,13S stereoisomer). It is isolated from Penicillium sp.PF1163 and exhibits antifungal activity against the pathogenic fungal strain Candida albicans TIMM1768.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C27H43NO6
Net Charge 0
Average Mass 477.63340
Monoisotopic Mass 477.30904
InChI InChI=1S/C27H43NO6/c1-4-7-22(30)19-24-13-10-20(2)8-5-6-9-26(31)28(3)25(27(32)34-24)18-21-11-14-23(15-12-21)33-17-16-29/h11-12,14-15,20,22,24-25,29-30H,4-10,13,16-19H2,1-3H3/t20-,22+,24+,25+/m1/s1
InChIKey SDBGPLZSWIQIOV-VQPAQMSKSA-N
SMILES CCC[C@H](O)C[C@@H]1CC[C@H](C)CCCCC(=O)N(C)[C@@H](Cc2ccc(OCCO)cc2)C(=O)O1
Metabolite of Species Details
Penicillium (NCBI:txid5073) of strain PF1163 See: PubMed
Roles Classification
Biological Role(s): Penicillium metabolite
Any fungal metabolite produced during a metabolic reaction in Penicillium.
antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
(via macrolide antibiotic )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing PF 1163A (CHEBI:66740) has role Penicillium metabolite (CHEBI:76964)
PF 1163A (CHEBI:66740) has role antifungal agent (CHEBI:35718)
PF 1163A (CHEBI:66740) is a aromatic ether (CHEBI:35618)
PF 1163A (CHEBI:66740) is a lactam (CHEBI:24995)
PF 1163A (CHEBI:66740) is a macrolide antibiotic (CHEBI:25105)
PF 1163A (CHEBI:66740) is a secondary alcohol (CHEBI:35681)
IUPAC Name
(3S,10R,13S)-3-[4-(2-hydroxyethoxy)benzyl]-13-[(2S)-2-hydroxypentyl]-4,10-dimethyl-1-oxa-4-azacyclotridecane-2,5-dione
Synonym Source
(−)-PF 1163A ChEBI
Registry Number Type Source
8523092 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
10695680 PubMed citation Europe PMC
10724005 PubMed citation Europe PMC
10724006 PubMed citation Europe PMC
12546418 PubMed citation Europe PMC
Last Modified
13 January 2014