linifanib (CHEBI:91435)

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ChEBI Name	linifanib

ChEBI ID	CHEBI:91435

Definition	A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 2-fluoro-5-methylphenyl group, while the other is substituted by a p-(3-amino-1H-indazol-4-yl)phenyl group. It is a potent, selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinases.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C21H18FN5O

Net Charge

Average Mass

375.400

Monoisotopic Mass

375.14954

InChI

InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)

InChIKey

MPVGZUGXCQEXTM-UHFFFAOYSA-N

SMILES

CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.

ChEBI Ontology
Outgoing	linifanib (CHEBI:91435) has role angiogenesis inhibitor (CHEBI:48422) linifanib (CHEBI:91435) has role antineoplastic agent (CHEBI:35610) linifanib (CHEBI:91435) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434) linifanib (CHEBI:91435) is a aromatic amine (CHEBI:33860) linifanib (CHEBI:91435) is a indazoles (CHEBI:38769) linifanib (CHEBI:91435) is a phenylureas (CHEBI:134043)

Synonyms	Sources
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea	LINCS
ABT 869	ChemIDplus
ABT-869	ChemIDplus
ABT869	ChEBI
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea	ChemIDplus

Last Modified

10 December 2016