AMG-208 (CHEBI:90626)

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ChEBI Name	AMG-208

ChEBI ID	CHEBI:90626

Definition	A member of the class of quinolines that is 7-methoxyquinoline substituted at position 4 by a (6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy group. AMG exhibits antitumour activity, particularly in prostate cancer.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Matthias Ziehm

Supplier Information

Download	Molfile XML SDF

Formula

C22H17N5O2

Net Charge

Average Mass

383.404

Monoisotopic Mass

383.13822

InChI

InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3

InChIKey

HEAIZQNMNCHNFD-UHFFFAOYSA-N

SMILES

N1=C(C2=CC=CC=C2)C=CC3=NN=C(COC4=C5C(C=C(C=C5)OC)=NC=C4)N13

Roles Classification
Biological Role(s):	c-Met tyrosine kinase inhibitor An EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor that interferes with the action of c-Met tyrosine kinase.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	AMG-208 (CHEBI:90626) has role antineoplastic agent (CHEBI:35610) AMG-208 (CHEBI:90626) has role c-Met tyrosine kinase inhibitor (CHEBI:90199) AMG-208 (CHEBI:90626) is a aromatic ether (CHEBI:35618) AMG-208 (CHEBI:90626) is a quinolines (CHEBI:26513) AMG-208 (CHEBI:90626) is a triazolopyridazine (CHEBI:48384)

IUPAC Name

7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline

Registry Number	Type	Source
1002304-34-8	CAS Registry Number	ChemIDplus

Last Modified

11 July 2018