mitoguazone (CHEBI:43996)

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ChEBI Name	mitoguazone

ChEBI ID	CHEBI:43996

Definition	A hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C5H12N8

Net Charge

Average Mass

184.20240

Monoisotopic Mass

184.11849

InChI

InChI=1S/C5H12N8/c1-3(11-13-5(8)9)2-10-12-4(6)7/h2H,1H3,(H4,6,7,12)(H4,8,9,13)/b10-2+,11-3+

InChIKey

MXWHMTNPTTVWDM-NXOFHUPFSA-N

SMILES

C\C(\C=N\NC(N)=N)=N/NC(N)=N

Roles Classification
Biological Role(s):	apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor An EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of adenosylmethionine decarboxylase (EC 4.1.1.50).

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	mitoguazone (CHEBI:43996) has functional parent aminoguanidine (CHEBI:40618) mitoguazone (CHEBI:43996) has functional parent methylglyoxal (CHEBI:17158) mitoguazone (CHEBI:43996) has role antineoplastic agent (CHEBI:35610) mitoguazone (CHEBI:43996) has role apoptosis inducer (CHEBI:68495) mitoguazone (CHEBI:43996) has role EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor (CHEBI:78024) mitoguazone (CHEBI:43996) is a guanidines (CHEBI:24436) mitoguazone (CHEBI:43996) is a hydrazone (CHEBI:38532) mitoguazone (CHEBI:43996) is conjugate base of mitoguazone(2+) (CHEBI:78025)

Incoming	mitoguazone(2+) (CHEBI:78025) is conjugate acid of mitoguazone (CHEBI:43996)

Synonyms	Sources
Me-GAG	ChemIDplus
Methyl-Gag	ChemIDplus
Methylglyoxal bis(amidinohydrazone)	ChemIDplus
Methylglyoxal bis(guanylhydrazone)	ChemIDplus
MGBG	MetaCyc
Pyruvaldehyde bis(amidinohydrazone)	ChemIDplus

Last Modified

22 February 2017