PJ34 (CHEBI:167900)

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ChEBI Name	PJ34

ChEBI ID	CHEBI:167900

Definition	A member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC₅₀ of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Margaret Duesbury

Secondary ChEBI IDs	CHEBI:44653

Supplier Information

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Formula

C17H17N3O2

Net Charge

Average Mass

295.342

Monoisotopic Mass

295.13208

InChI

InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22)

InChIKey

UYJZZVDLGDDTCL-UHFFFAOYSA-N

SMILES

CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=CC=CC=C23)C=C1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of a NAD+ ADP-ribosyltransferase (EC 2.4.2.30). apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. antiatherosclerotic agent A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent. cardioprotective agent Any protective agent that is able to prevent damage to the heart. anti-inflammatory agent Any compound that has anti-inflammatory effects. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders.

ChEBI Ontology
Outgoing	PJ34 (CHEBI:167900) has role angiogenesis inhibitor (CHEBI:48422) PJ34 (CHEBI:167900) has role anti-inflammatory agent (CHEBI:67079) PJ34 (CHEBI:167900) has role antiatherosclerotic agent (CHEBI:145947) PJ34 (CHEBI:167900) has role antineoplastic agent (CHEBI:35610) PJ34 (CHEBI:167900) has role apoptosis inducer (CHEBI:68495) PJ34 (CHEBI:167900) has role cardioprotective agent (CHEBI:77307) PJ34 (CHEBI:167900) has role EC 2.4.2.30 (NAD⁺ ADP-ribosyltransferase) inhibitor (CHEBI:62913) PJ34 (CHEBI:167900) has role neuroprotective agent (CHEBI:63726) PJ34 (CHEBI:167900) is a phenanthridines (CHEBI:51245) PJ34 (CHEBI:167900) is a secondary carboxamide (CHEBI:140325) PJ34 (CHEBI:167900) is a tertiary amino compound (CHEBI:50996) PJ34 (CHEBI:167900) is conjugate base of PJ34(1+) (CHEBI:167903)

Incoming	PJ34(1+) (CHEBI:167903) is conjugate acid of PJ34 (CHEBI:167900)

IUPAC Name

2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide

Synonyms	Sources
2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide	ChEBI
2-(dimethylaminoacetylamino)-5,6-dihydrophenanthridine-6-one	ChEBI
N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)acetamide	ChEBI
N-(5,6-dihydro-6-oxophenanthridine-2-yl)-2-(dimethylamino)acetamide	ChEBI
N²,N²-dimethyl-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide	IUPAC
PJ 34	ChEBI
PJ-34	ChEBI

Registry Number	Type	Source
344458-19-1	CAS Registry Number	ChEBI

Last Modified

07 April 2021