1-(3-chlorophenyl)piperazine (CHEBI:10588)

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ChEBI Name	1-(3-chlorophenyl)piperazine

ChEBI ID	CHEBI:10588

Definition	A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C10H13ClN2

Net Charge

Average Mass

196.67640

Monoisotopic Mass

196.07673

InChI

InChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2

InChIKey

VHFVKMTVMIZMIK-UHFFFAOYSA-N

SMILES

Clc1cccc(c1)N1CCNCC1

Roles Classification
Chemical Role(s):	environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	drug metabolite serotonergic agonist An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.

Application(s):	serotonergic agonist An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.

ChEBI Ontology
Outgoing	1-(3-chlorophenyl)piperazine (CHEBI:10588) has role drug metabolite (CHEBI:49103) 1-(3-chlorophenyl)piperazine (CHEBI:10588) has role environmental contaminant (CHEBI:78298) 1-(3-chlorophenyl)piperazine (CHEBI:10588) has role serotonergic agonist (CHEBI:35941) 1-(3-chlorophenyl)piperazine (CHEBI:10588) has role xenobiotic (CHEBI:35703) 1-(3-chlorophenyl)piperazine (CHEBI:10588) is a N-arylpiperazine (CHEBI:46848) 1-(3-chlorophenyl)piperazine (CHEBI:10588) is a monochlorobenzenes (CHEBI:83403)

IUPAC Name

1-(3-chlorophenyl)piperazine

Manual Xrefs	Databases
C11738	KEGG COMPOUND
HMDB0061008	HMDB
LSM-25627	LINCS
Meta-Chlorophenylpiperazine	Wikipedia
View more database links

Last Modified

25 February 2016