flavokawain B (CHEBI:65899)

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ChEBI Name	flavokawain B

ChEBI ID	CHEBI:65899

Definition	A member of the class of chalcones that consists of trans-chalcone substituted by hydroxy group at positions 2' and methoxy groups at positions 4' and 6'. Isolated from Piper methysticum and Piper rusbyi, it exhibits antileishmanial, anti-inflammatory and antineoplastic activities.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C17H16O4

Net Charge

Average Mass

284.30650

Monoisotopic Mass

284.10486

InChI

InChI=1S/C17H16O4/c1-20-13-10-15(19)17(16(11-13)21-2)14(18)9-8-12-6-4-3-5-7-12/h3-11,19H,1-2H3/b9-8+

InChIKey

QKQLSQLKXBHUSO-CMDGGOBGSA-N

SMILES

COc1cc(O)c(C(=O)\C=C\c2ccccc2)c(OC)c1

Roles Classification
Biological Role(s):	antileishmanial agent An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.

Application(s):	antileishmanial agent An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania. anti-inflammatory agent Any compound that has anti-inflammatory effects. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	flavokawain B (CHEBI:65899) has functional parent trans-chalcone (CHEBI:48965) flavokawain B (CHEBI:65899) has role anti-inflammatory agent (CHEBI:67079) flavokawain B (CHEBI:65899) has role antileishmanial agent (CHEBI:70868) flavokawain B (CHEBI:65899) has role antineoplastic agent (CHEBI:35610) flavokawain B (CHEBI:65899) has role apoptosis inducer (CHEBI:68495) flavokawain B (CHEBI:65899) has role metabolite (CHEBI:25212) flavokawain B (CHEBI:65899) is a chalcones (CHEBI:23086) flavokawain B (CHEBI:65899) is a dimethoxybenzene (CHEBI:51681) flavokawain B (CHEBI:65899) is a phenols (CHEBI:33853)

IUPAC Name

(2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one

Last Modified

25 January 2013