CHEBI:76274 - SC560

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ChEBI Name SC560
ChEBI ID CHEBI:76274
Definition A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-methoxyphenyl, trifluoromethyl and 4-chlorophenyl groups, respectively. Unlike many members of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors, SC-560 is selective for COX-1.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C17H12ClF3N2O
Net Charge 0
Average Mass 352.73800
Monoisotopic Mass 352.05903
InChI InChI=1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
InChIKey PQUGCKBLVKJMNT-UHFFFAOYSA-N
SMILES COc1ccc(cc1)-n1nc(cc1-c1ccc(Cl)cc1)C(F)(F)F
Roles Classification
Biological Role(s): cyclooxygenase 1 inhibitor
A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): angiogenesis modulating agent
An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
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ChEBI Ontology
Outgoing SC560 (CHEBI:76274) has role angiogenesis modulating agent (CHEBI:50926)
SC560 (CHEBI:76274) has role antineoplastic agent (CHEBI:35610)
SC560 (CHEBI:76274) has role apoptosis inducer (CHEBI:68495)
SC560 (CHEBI:76274) has role cyclooxygenase 1 inhibitor (CHEBI:50630)
SC560 (CHEBI:76274) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
SC560 (CHEBI:76274) is a aromatic ether (CHEBI:35618)
SC560 (CHEBI:76274) is a monochlorobenzenes (CHEBI:83403)
SC560 (CHEBI:76274) is a organofluorine compound (CHEBI:37143)
SC560 (CHEBI:76274) is a pyrazoles (CHEBI:26410)
IUPAC Name
5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Synonyms Sources
5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole ChemIDplus
SC 560 ChEBI
SC-560 ChEBI
Manual Xrefs Databases
LSM-2314 LINCS
WO2008076703 Patent
View more database links
Registry Numbers Types Sources
188817-13-2 CAS Registry Number ChemIDplus
7719788 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
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Last Modified
21 April 2016