tubulozole (CHEBI:83928)

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ChEBI Name	tubulozole

ChEBI ID	CHEBI:83928

Definition	A racemate comprising equimolar amounts of (2R,4R)- and (2S,4S)-tubulozole. A synthetic anticancer drug that interferes with the structure and function of microtubules in both interphase and mitotic cells.

Stars	This entity has been manually annotated by the ChEBI Team.

Roles Classification
Biological Role(s):	microtubule-destabilising agent Any substance that interacts with tubulin to inhibit polymerisation of microtubules.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	tubulozole (CHEBI:83928) has part (R,R)-tubulozole (CHEBI:83932) tubulozole (CHEBI:83928) has part (S,S)-tubulozole (CHEBI:83933) tubulozole (CHEBI:83928) has role antineoplastic agent (CHEBI:35610) tubulozole (CHEBI:83928) has role microtubule-destabilising agent (CHEBI:61951) tubulozole (CHEBI:83928) is a racemate (CHEBI:60911)

IUPAC Names

rac-ethyl [4-({[(2R,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)phenyl]carbamate

rac-ethyl [4-({[(2S,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)phenyl]carbamate

Synonyms	Sources
Ethyl (+-)-cis-p-(((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-p-ylmethylthio)thio))carbanilate	ChemIDplus
R 46846	ChemIDplus
Tubulozole C	ChemIDplus

Last Modified

28 November 2014