diphemanil methylsulfate (CHEBI:59782)

ChEBI > Main

Main

ChEBI Ontology

Automatic Xrefs

Reactions

Pathways

Models

ChEBI Name	diphemanil methylsulfate

ChEBI ID	CHEBI:59782

Definition	The alkene resulting from the formal Wittig olefination of benzophenone and 1,1-dimethyl-4-bromopiperidinium methylsulfate. A quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids, saliva and sweat, It is used topically in the treatment of hyperhidorsis (excessive sweating).

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Wikipedia	License

Read full article at Wikipedia

Formula

C21H27NO4S

Net Charge

Average Mass

389.50800

Monoisotopic Mass

389.16608

InChI

InChI=1S/C20H24N.CH4O4S/c1-21(2)15-13-19(14-16-21)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;1-5-6(2,3)4/h3-12H,13-16H2,1-2H3;1H3,(H,2,3,4)/q+1;/p-1

InChIKey

BREMLQBSKCSNNH-UHFFFAOYSA-M

SMILES

COS([O-])(=O)=O.C[N+]1(C)CCC(CC1)=C(c1ccccc1)c1ccccc1

Roles Classification
Biological Role(s):	muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. parasympatholytic Any cholinergic antagonist that inhibits the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the muscarinic antagonists.

Application(s):	muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. parasympatholytic Any cholinergic antagonist that inhibits the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the muscarinic antagonists. bronchodilator agent An agent that causes an increase in the expansion of a bronchus or bronchial tubes.

ChEBI Ontology
Outgoing	diphemanil methylsulfate (CHEBI:59782) has role bronchodilator agent (CHEBI:35523) diphemanil methylsulfate (CHEBI:59782) has role muscarinic antagonist (CHEBI:48876) diphemanil methylsulfate (CHEBI:59782) has role parasympatholytic (CHEBI:50370) diphemanil methylsulfate (CHEBI:59782) is a piperidines (CHEBI:26151) diphemanil methylsulfate (CHEBI:59782) is a quaternary ammonium salt (CHEBI:35273)

IUPAC Name

4-(diphenylmethylidene)-1,1-dimethylpiperidinium methyl sulfate

Synonyms	Sources
4-(diphenylmethylene)-1,1-dimethylpiperidinium methyl sulfate	ChemIDplus
diphemanil methosulfate	ChemIDplus
diphemanil metilsulfate	ChEBI
N,N-dimethyl-4-piperidylidene-1,1-diphenylmethane methylsulfate	ChEBI
p-(α-phenylbenzylidene)-1,1-dimethylpiperidinium methyl sulfate	ChemIDplus

Last Modified

19 July 2010