CHEBI:4887 - ethosuximide

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ChEBI Name ethosuximide
Definition A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:131811
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Formula C7H11NO2
Net Charge 0
Average Mass 141.16770
Monoisotopic Mass 141.07898
InChI InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
Roles Classification
Biological Role(s): calcium channel blocker
One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
Application(s): anticonvulsant
A drug used to prevent seizures or reduce their severity.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing ethosuximide (CHEBI:4887) has role anticonvulsant (CHEBI:35623)
ethosuximide (CHEBI:4887) has role calcium channel blocker (CHEBI:38215)
ethosuximide (CHEBI:4887) is a dicarboximide (CHEBI:35356)
ethosuximide (CHEBI:4887) is a pyrrolidinone (CHEBI:38275)
Incoming (R)-ethosuximide (CHEBI:60354) is a ethosuximide (CHEBI:4887)
(S)-ethosuximide (CHEBI:60355) is a ethosuximide (CHEBI:4887)
INNs Sources
éthosuximide WHO MedNet
ethosuximide ChemIDplus
ethosuximidum ChemIDplus
etosuximida ChemIDplus
Synonyms Sources
(±)-2-ethyl-2-methylsuccinimide ChemIDplus
2-ethyl-2-methylsuccinimide ChemIDplus
2-methyl-2-ethylsuccinimide ChemIDplus
3-ethyl-3-methyl-2,5-pyrrolidinedione ChEBI
3-ethyl-3-methylsuccinimide ChemIDplus
3-methyl-3-ethylpyrrolidine-2,5-dione ChemIDplus
3-methyl-3-ethylsuccinimide ChemIDplus
Aethosuximide ChemIDplus
α-ethyl-α-methylsuccinimide ChemIDplus
α-methyl-α-ethylsuccinimide ChemIDplus
Ethosuximide KEGG COMPOUND
γ-ethyl-γ-methyl-succinimide ChEBI
γ-methyl-γ-ethyl-succinimide ChemIDplus
Manual Xrefs Databases
1087 DrugCentral
DB00593 DrugBank
Ethosuximide Wikipedia
HMDB0014731 HMDB
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Registry Numbers Types Sources
117054 Reaxys Registry Number Reaxys
77-67-8 CAS Registry Number NIST Chemistry WebBook
77-67-8 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
22 February 2017