InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1 |
HKVAMNSJSFKALM-GKUWKFKPSA-N |
[H][C@]1(CC[C@@H](OCCO)[C@@H](C1)OC)C[C@@H](C)[C@]1([H])CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@]2([H])CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@@]2([H])C(=O)O1)OC |
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immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
mTOR inhibitor
A protein kinase inhibitor of the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. mTOR inhibitors are used to prevent transplant rejection and in treatment of cancer.
anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
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immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
geroprotector
Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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View more via ChEBI Ontology
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
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évérolimus
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WHO MedNet
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everolimus
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WHO MedNet
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everolimus
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WHO MedNet
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everolimusum
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WHO MedNet
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(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,35R)-1,18-dihydroxy-12-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
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IUPAC
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40-O-(2-hydroxyethyl)-rapamycin
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ChemIDplus
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42-O-(2-hydroxyethyl)rapamycin
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ChemIDplus
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Everolimus
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ChemIDplus
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RAD 001
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ChemIDplus
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RAD001
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ChemIDplus
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SDZ RAD
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ChemIDplus
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SDZ-RAD
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ChemIDplus
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Afinitor
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ChemIDplus
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Afinitor Disperz
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ChemIDplus
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Certican
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ChemIDplus
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Votubia
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DrugCentral
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Xience V
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ChemIDplus
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Zortress
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ChemIDplus
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159351-69-6
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CAS Registry Number
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ChemIDplus
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22363408
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PubMed citation
|
Europe PMC
|
22404500
|
PubMed citation
|
Europe PMC
|
22461124
|
PubMed citation
|
Europe PMC
|
22683823
|
PubMed citation
|
Europe PMC
|
22967800
|
PubMed citation
|
Europe PMC
|
22969095
|
PubMed citation
|
Europe PMC
|
22983698
|
PubMed citation
|
Europe PMC
|
22986894
|
PubMed citation
|
Europe PMC
|
31478889
|
PubMed citation
|
Europe PMC
|
33640871
|
PubMed citation
|
Europe PMC
|
33986025
|
PubMed citation
|
Europe PMC
|
33998365
|
PubMed citation
|
Europe PMC
|
34018490
|
PubMed citation
|
Europe PMC
|
34225066
|
PubMed citation
|
Europe PMC
|
34242751
|
PubMed citation
|
Europe PMC
|
34253597
|
PubMed citation
|
Europe PMC
|
34299359
|
PubMed citation
|
Europe PMC
|
34467233
|
PubMed citation
|
Europe PMC
|
34491881
|
PubMed citation
|
Europe PMC
|
34527569
|
PubMed citation
|
Europe PMC
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