CHEBI:141517 - tyloxapol

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ChEBI Name tyloxapol
ChEBI ID CHEBI:141517
Definition A polymeric compound resulting from the reaction of 4-(1,1,3,3-tetramethylbutyl)phenol with formaldehyde to give a chain in which 6-8 molecules are linked together by CH2 groups ortho to the phenolic hydroxy groups, which have then undergone reaction with oxirane to give polyoxyethyleneoxy moieties, Ar(OCH2CH2)xOH, where x = 8-10. A nonionic liquic polymer, it inhibits lipoprotein lipase and hence clearance of triglyceride from the plasma, so is used to induce hyperlipidaemia in test animals. Also used as a surfactant to aid liquefaction and removal of mucus- and pus-containing bronchopulmonary secretions.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Sabrina Toro
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Formula (C2H4O)n.(C2H4O)n.(C17H26O2)n.(C2H4O)n.C29H44O2
Net Charge 0
Roles Classification
Chemical Role(s): surfactant
A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces.
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
inhibitor
A substance that diminishes the rate of a chemical reaction.
Application(s): excipient
A generally pharmacologically inactive substance that is formulated with the active ingredient of a medication.
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ChEBI Ontology
Outgoing tyloxapol (CHEBI:141517) has role apoptosis inducer (CHEBI:68495)
tyloxapol (CHEBI:141517) has role excipient (CHEBI:75324)
tyloxapol (CHEBI:141517) has role inhibitor (CHEBI:35222)
tyloxapol (CHEBI:141517) has role surfactant (CHEBI:35195)
tyloxapol (CHEBI:141517) is a polymer (CHEBI:60027)
INNs Sources
tiloxapol ChemIDplus
tyloxapol ChemIDplus
tyloxapol ChemIDplus
tyloxapolum ChEBI
Synonyms Sources
4-(1,1,2,2-tetramethylbutyl)phenol polyer with formaldehyde and oxirane ChEBI
oxyethylated tertiary octylphenol formaldehyde polymer ChEBI
p-(1,1,3,3-tetramethylbutyl)phenol polymer with ethylene oxide and formaldehyde ChemIDplus
p-isooctylpolyoxyethylenenphenol formaldehyde polymer ChEBI
tyloxypal ChEBI
Brand Names Sources
Alevaire ChEBI
Superinone ChEBI
Triton A-20 ChEBI
Triton WR-1339 ChEBI
Manual Xrefs Databases
4738 DrugCentral
D03261 KEGG DRUG
DB06439 DrugBank
EP0602702 Patent
Tyloxapol Wikipedia
US2454541 Patent
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Registry Number Type Source
25301-02-4 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
16779702 PubMed citation Europe PMC
25182386 PubMed citation Europe PMC
26949944 PubMed citation Europe PMC
27308826 PubMed citation Europe PMC
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28432556 PubMed citation Europe PMC
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Last Modified
08 October 2018