CHEBI:35677 - betahistine

Main

ChEBI Ontology

Automatic Xrefs

Reactions

Pathways

Models

ChEBI Name betahistine ChEBI ID CHEBI:35677 Definition An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Ménière's disease. Stars This entity has been manually annotated by the ChEBI Team. Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Wikipedia License Read full article at Wikipedia Formula C8H12N2 Net Charge 0 Average Mass 136.19430 Monoisotopic Mass 136.10005 InChI InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3 InChIKey UUQMNUMQCIQDMZ-UHFFFAOYSA-N SMILES CNCCc1ccccn1 Roles Classification Chemical Role(s): Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound ) Biological Role(s): H1-receptor agonist A histamine agonist that binds to and activates H1-receptors. Application(s): H1-receptor agonist A histamine agonist that binds to and activates H1-receptors. vasodilator agent A drug used to cause dilation of the blood vessels. View more via ChEBI Ontology ChEBI Ontology Outgoing betahistine (CHEBI:35677) has role H1-receptor agonist (CHEBI:71173) betahistine (CHEBI:35677) has role vasodilator agent (CHEBI:35620) betahistine (CHEBI:35677) is a aminoalkylpyridine (CHEBI:38198) betahistine (CHEBI:35677) is a secondary amino compound (CHEBI:50995) IUPAC Name N-methyl-2-pyridin-2-ylethanamine INNs Sources betahistina WHO MedNet bétahistine WHO MedNet betahistine WHO MedNet betahistinum WHO MedNet Synonyms Sources 2-(β-methylaminoethyl)pyridine NIST Chemistry WebBook 2-[2-(methylamino)ethyl]pyridine NIST Chemistry WebBook [2-(2-pyridyl)ethyl]methylamine NIST Chemistry WebBook N-methyl-2-(2-pyridinyl)ethanamine NIST Chemistry WebBook N-methyl-2-pyridineethanamine ChemIDplus Manual Xrefs Databases 346 DrugCentral Betahistine Wikipedia D07522 KEGG DRUG DB06698 DrugBank HMDB0015644 HMDB LSM-4044 LINCS View more database links Registry Numbers Types Sources 112294 Reaxys Registry Number Reaxys 112294 Beilstein Registry Number Beilstein 5638-76-6 CAS Registry Number NIST Chemistry WebBook 5638-76-6 CAS Registry Number ChemIDplus Citations Types Sources 20530654 PubMed citation Europe PMC 22365373 PubMed citation Europe PMC 22745706 PubMed citation Europe PMC 7589314 PubMed citation Europe PMC Last Modified 22 February 2017