ergoloid mesylate (CHEBI:34706)

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ChEBI Name	ergoloid mesylate

ChEBI ID	CHEBI:34706

Definition	A mixture of hydrogenated ergot alkaloids consisting of the methanesulfonic acid salts of dihydroergocornine (R = CHMe₂), dihydroergocristine (R = CH₂Ph), and α- and β-dihydroergocryptine (R = CH₂CHMe₂ and CH(Me)Et, respectively). It is used for the symptomatic treatment of mild to moderate dementia in the elderly, although its value is not established.

Stars	This entity has been manually annotated by the ChEBI Team.

Download	Molfile XML SDF

Formula

C29H38N5O8SR

Net Charge

Average Mass (excl. R groups)

616.708

Monoisotopic Mass (excl. R groups)

616.24411

SMILES

C1=CC=C2NC=C3C[C@@]4([C@](C[C@H](CN4C)C(N[C@]5(C(N6[C@@](O5)([C@]7(N(C([C@@H]6*)=O)CCC7)[H])O)=O)C(C)C)=O)(C1=C32)[H])[H].OS(C)(=O)=O

Roles Classification
Biological Role(s):	alpha-adrenergic antagonist An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. sympatholytic agent Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).

Application(s):	alpha-adrenergic antagonist An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. vasodilator agent A drug used to cause dilation of the blood vessels. sympatholytic agent Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS). nootropic agent Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration.

ChEBI Ontology
Outgoing	ergoloid mesylate (CHEBI:34706) has part dihydro-α-ergocryptine mesylate (CHEBI:31487) ergoloid mesylate (CHEBI:34706) has part dihydro-β-ergocryptine mesylate (CHEBI:34704) ergoloid mesylate (CHEBI:34706) has part dihydroergocornine mesylate (CHEBI:34502) ergoloid mesylate (CHEBI:34706) has part dihydroergocristine mesylate (CHEBI:31490) ergoloid mesylate (CHEBI:34706) has role α-adrenergic antagonist (CHEBI:37890) ergoloid mesylate (CHEBI:34706) has role nootropic agent (CHEBI:66980) ergoloid mesylate (CHEBI:34706) has role sympatholytic agent (CHEBI:66991) ergoloid mesylate (CHEBI:34706) has role vasodilator agent (CHEBI:35620) ergoloid mesylate (CHEBI:34706) is a methanesulfonate salt (CHEBI:38037)

Synonyms	Sources
co-dergocrine mesilate	ChEBI
co-dergocrine mesylate	ChEBI
co-dergocrine methanesulfonate	ChEBI
codergocrine mesilate	ChEBI
codergocrine mesylate	ChEBI
codergocrine methanesulfonate	ChEBI
Dihydroergotoxine mesilate	KEGG COMPOUND
Dihydroergotoxine mesylate	KEGG COMPOUND
dihydroergotoxine methanesulfonate	ChemIDplus
dihydroergotoxine methanesulfonates	ChEBI
dihydroergotoxine monomethanesulfonate	ChemIDplus
dihydrogenated ergot alkaloids	ChEBI
Ergoloid mesylates	KEGG COMPOUND
ergoloid mesylates	ChEBI
ergoloid methanesulfonate	ChEBI
ergoloid methanesulfonates	ChEBI
hydrogenated ergot alkaloids	ChEBI

Last Modified

03 December 2019