hydroflumethiazide (CHEBI:5784)

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ChEBI Name	hydroflumethiazide

ChEBI ID	CHEBI:5784

Definition	A benzothiadiazine consisting of a 3,4-dihydro-HH-1,2,4-benzothiadiazine bicyclic system dioxygenated on sulfur and carrying trifluoromethyl and aminosulfonyl groups at positions 6 and 7 respectively. A diuretic with actions and uses similar to those of hydrochlorothiazide.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C8H8F3N3O4S2

Net Charge

Average Mass

331.295

Monoisotopic Mass

330.99083

InChI

InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)

InChIKey

DMDGGSIALPNSEE-UHFFFAOYSA-N

SMILES

C12=C(C=C(S(N)(=O)=O)C(=C1)C(F)(F)F)S(NCN2)(=O)=O

Roles Classification
Application(s):	diuretic An agent that promotes the excretion of urine through its effects on kidney function. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.

ChEBI Ontology
Outgoing	hydroflumethiazide (CHEBI:5784) has role antihypertensive agent (CHEBI:35674) hydroflumethiazide (CHEBI:5784) has role diuretic (CHEBI:35498) hydroflumethiazide (CHEBI:5784) is a benzothiadiazine (CHEBI:50265) hydroflumethiazide (CHEBI:5784) is a thiazide (CHEBI:50264)

IUPAC Name

6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Synonyms	Sources
Hydroflumethiazide	KEGG COMPOUND
trifluoromethylhydrothiazide	DrugCentral

Last Modified

12 June 2018