nitrendipine (CHEBI:7582)

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ChEBI Name	nitrendipine

ChEBI ID	CHEBI:7582

Definition	A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C18H20N2O6

Net Charge

Average Mass

360.36120

Monoisotopic Mass

360.13214

InChI

InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3

InChIKey

PVHUJELLJLJGLN-UHFFFAOYSA-N

SMILES

CCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC

Roles Classification
Biological Role(s):	calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.

Application(s):	geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. vasodilator agent A drug used to cause dilation of the blood vessels.

ChEBI Ontology
Outgoing	nitrendipine (CHEBI:7582) has role antihypertensive agent (CHEBI:35674) nitrendipine (CHEBI:7582) has role calcium channel blocker (CHEBI:38215) nitrendipine (CHEBI:7582) has role geroprotector (CHEBI:176497) nitrendipine (CHEBI:7582) has role vasodilator agent (CHEBI:35620) nitrendipine (CHEBI:7582) is a C-nitro compound (CHEBI:35716) nitrendipine (CHEBI:7582) is a dicarboxylic acids and O-substituted derivatives (CHEBI:131927) nitrendipine (CHEBI:7582) is a diester (CHEBI:51307) nitrendipine (CHEBI:7582) is a dihydropyridine (CHEBI:50075) nitrendipine (CHEBI:7582) is a ethyl ester (CHEBI:23990) nitrendipine (CHEBI:7582) is a methyl ester (CHEBI:25248)

IUPAC Name

ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Synonyms	Sources
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester	ChemIDplus
BAY e 5009	ChemIDplus

Last Modified

26 October 2021