CHEBI:34845 - metipranolol hydrochloride

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ChEBI Name metipranolol hydrochloride
ChEBI ID CHEBI:34845
Definition The hydrochloride salt of metipranolol. A non-cardioselective beta-blocker, it is used to lower intra-ocular pressure in the management of open-angle glaucoma.
Stars This entity has been manually annotated by the ChEBI Team.
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Formulae C17H27NO4.HCl
C17H28ClNO4
Net Charge 0
Average Mass 345.86200
Monoisotopic Mass 345.17069
InChI InChI=1S/C17H27NO4.ClH/c1-10(2)18-8-15(20)9-21-16-7-11(3)17(22-14(6)19)13(5)12(16)4;/h7,10,15,18,20H,8-9H2,1-6H3;1H
InChIKey BLWNYSZZZWQCKO-UHFFFAOYSA-N
SMILES [Cl-].CC(C)[NH2+]CC(O)COc1cc(C)c(OC(C)=O)c(C)c1C
Roles Classification
Biological Role(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
Application(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
anti-arrhythmia drug
A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
antiglaucoma drug
Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.
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ChEBI Ontology
Outgoing metipranolol hydrochloride (CHEBI:34845) has role β-adrenergic antagonist (CHEBI:35530)
metipranolol hydrochloride (CHEBI:34845) has role anti-arrhythmia drug (CHEBI:38070)
metipranolol hydrochloride (CHEBI:34845) has role antiglaucoma drug (CHEBI:39456)
metipranolol hydrochloride (CHEBI:34845) has role antihypertensive agent (CHEBI:35674)
metipranolol hydrochloride (CHEBI:34845) is a organic chloride salt (CHEBI:36094)
IUPAC Name
4-[2-hydroxy-3-(propan-2-ylamino)propoxy]-2,3,6-trimethylphenyl acetate hydrochloride
Synonyms Sources
3-[4-(acetyloxy)-2,3,5-trimethylphenoxy]-2-hydroxy-N-(propan-2-yl)propan-1-aminium chloride IUPAC
metipranolol HCl ChEBI
Metipranolol hydrochloride KEGG COMPOUND
Manual Xrefs Databases
C13591 KEGG COMPOUND
D02081 KEGG DRUG
DB01214 DrugBank
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Registry Numbers Types Sources
36592-77-5 CAS Registry Number ChemIDplus
6673751 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
2873545 PubMed citation Europe PMC
7916025 PubMed citation Europe PMC
Last Modified
04 August 2014