CHEBI:156497 - novolactone

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ChEBI Name novolactone
ChEBI ID CHEBI:156497
Definition A natural product isolated from a fungal strain closely related to Aporospora terricola. It is an allosteric inhibitor of Hsp70.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Micheal Alexander
Supplier Information
Download Molfile XML SDF
Formula C20H28O4
Net Charge 0
Average Mass 332.440
Monoisotopic Mass 332.19876
InChI InChI=1S/C20H28O4/c1-5-12-6-7-14-13(11(12)2)10-15(21)20(23)18(14,3)9-8-16-19(20,4)17(22)24-16/h5-6,11,13-16,21,23H,1,7-10H2,2-4H3/t11-,13-,14-,15+,16-,18+,19+,20-/m0/s1
InChIKey GPFXZYJYVUTNSE-LCPICFLISA-N
SMILES [H][C@]12CC[C@]3(C)[C@@]4([H])CC=C(C=C)[C@H](C)[C@]4([H])C[C@@H](O)[C@@]3(O)[C@@]1(C)C(=O)O2
Metabolite of Species Details
Aporospora terricola (NCBI:txid73565) See: PubMed
Roles Classification
Biological Role(s): EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor
An EC 3.6.4.* (hydrolases acting on ATP; involved in cellular and subcellular movement) inhibitor that interferes with the action of a non-chaperonin molecular chaperone ATPase (EC 3.6.4.10).
fungal metabolite
Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing novolactone (CHEBI:156497) has role EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor (CHEBI:76939)
novolactone (CHEBI:156497) has role fungal metabolite (CHEBI:76946)
novolactone (CHEBI:156497) is a diterpene lactone (CHEBI:49193)
novolactone (CHEBI:156497) is a secondary alcohol (CHEBI:35681)
novolactone (CHEBI:156497) is a tetracyclic diterpenoid (CHEBI:52557)
IUPAC Name
13-ethenyl-5,6β-dihydroxy-14α-methyl-3β-3,15-epoxypodocarp-12-en-15-one
Synonym Source
(2aS,2bS,3R,4aS,5R,8aS,8bR,10aS)-6-ethenyl-2b,3-dihydroxy-2a,5,8b-trimethyl-2a,2b,3,4,4a,5,8,8a,8b,9,10,10a-dodecahydro-2H-phenanthro[2,1-b]oxet-2-one IUPAC
Citations Waiting for Citations Types Sources
25544045 PubMed citation SUBMITTER
27447295 PubMed citation Europe PMC
Last Modified
15 September 2020