CHEBI:65822 - EI-1511-3

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ChEBI Name EI-1511-3
ChEBI ID CHEBI:65822
Definition A polyene antibiotic isolated from the fermentation broth of Streptomyces sp.E-1625 that exhibits inhibitory activity towards the recombinant human interleukin-1β converting enzyme (ICE). It also shows weak antibacterial activity against strains like Enterococcus faecium, Staphylococcus aureus and Bacillus subtilis.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C27H30N2O7
Net Charge 0
Average Mass 494.53630
Monoisotopic Mass 494.20530
InChI InChI=1S/C27H30N2O7/c1-17(2)10-6-5-8-11-21(32)28-18-16-27(35,26-25(36-26)24(18)34)15-9-4-3-7-12-22(33)29-23-19(30)13-14-20(23)31/h3-9,11-12,15-17,25-26,30,35H,10,13-14H2,1-2H3,(H,28,32)(H,29,33)/b4-3+,6-5+,11-8+,12-7+,15-9+/t25-,26-,27+/m1/s1
InChIKey NUTSBYCZDOSSIV-FFXBEMEVSA-N
SMILES [H][C@]12O[C@@]1([H])[C@@](O)(C=C(NC(=O)\C=C\C=C\CC(C)C)C2=O)\C=C\C=C\C=C\C(=O)NC1=C(O)CCC1=O
Metabolite of Species Details
Streptomyces sp. (NCBI:txid1931) of strain E 1511 See: PubMed
Roles Classification
Biological Role(s): antibacterial agent
A substance (or active part thereof) that kills or slows the growth of bacteria.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
(via polyene antibiotic )
Application(s): anti-inflammatory agent
Any compound that has anti-inflammatory effects.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing EI-1511-3 (CHEBI:65822) has role anti-inflammatory agent (CHEBI:67079)
EI-1511-3 (CHEBI:65822) has role antibacterial agent (CHEBI:33282)
EI-1511-3 (CHEBI:65822) has role metabolite (CHEBI:25212)
EI-1511-3 (CHEBI:65822) is a cyclic ketone (CHEBI:3992)
EI-1511-3 (CHEBI:65822) is a enamide (CHEBI:51751)
EI-1511-3 (CHEBI:65822) is a enol (CHEBI:33823)
EI-1511-3 (CHEBI:65822) is a epoxide (CHEBI:32955)
EI-1511-3 (CHEBI:65822) is a polyene antibiotic (CHEBI:26177)
EI-1511-3 (CHEBI:65822) is a secondary carboxamide (CHEBI:140325)
EI-1511-3 (CHEBI:65822) is a tertiary alcohol (CHEBI:26878)
IUPAC Name
(2E,4E)-N-[(1S,5S,6R)-5-hydroxy-5-{(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopent-1-en-1-yl)amino]-7-oxohepta-1,3,5-trien-1-yl}-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-7-methylocta-2,4-dienamide
Registry Number Type Source
7630280 Reaxys Registry Number Reaxys
Citation Waiting for Citations Type Source
8982334 PubMed citation Europe PMC
Last Modified
07 March 2018