6-bromoindirubin-3'-oxime (CHEBI:86290)

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ChEBI Name	6-bromoindirubin-3'-oxime

ChEBI ID	CHEBI:86290

Definition	A member of the class of biindoles that is indirubin substituted at position 6 by a bromo group and in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	TheOtherDave

Secondary ChEBI IDs	CHEBI:47271

Supplier Information

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Formula

C16H10BrN3O2

Net Charge

Average Mass

356.17400

Monoisotopic Mass

354.99564

InChI

InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+

InChIKey

DDLZLOKCJHBUHD-WAVHTBQISA-N

SMILES

O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2cc(Br)ccc12

Roles Classification
Biological Role(s):	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine. EC 2.7.11.26 (tau-protein kinase) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of tau-protein kinase inhibitor (EC 2.7.11.26).

ChEBI Ontology
Outgoing	6-bromoindirubin-3'-oxime (CHEBI:86290) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925) 6-bromoindirubin-3'-oxime (CHEBI:86290) has role EC 2.7.11.26 (tau-protein kinase) inhibitor (CHEBI:91092) 6-bromoindirubin-3'-oxime (CHEBI:86290) is a biindole (CHEBI:48594) 6-bromoindirubin-3'-oxime (CHEBI:86290) is a ketoxime (CHEBI:24983) 6-bromoindirubin-3'-oxime (CHEBI:86290) is a organobromine compound (CHEBI:37141) 6-bromoindirubin-3'-oxime (CHEBI:86290) is a oxindoles (CHEBI:38459)

IUPAC Name

(3Z)-6-bromo-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

Synonyms	Sources
(2Z,3E)-6'-bromo-2,3'-biindole-2',3(1H,1'H)-dione 3-oxime	PDBeChem
(2Z,3E)-6-Bromoindirubin-3'-oxime	SUBMITTER
6-BIO	SUBMITTER

Registry Number	Type	Source
9653830	Reaxys Registry Number	Reaxys

Last Modified

26 February 2016