CHEBI:76167 - lonazolac calcium

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ChEBI Name lonazolac calcium
ChEBI ID CHEBI:76167
Definition An organic calcium salt having [3-(4-chlorophenyl)-1-phenylpyrazol-4-yl]acetate as the counterion.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C34H24CaCl2N4O4
Net Charge 0
Average Mass 663.56300
Monoisotopic Mass 662.08005
InChI InChI=1S/2C17H13ClN2O2.Ca/c2*18-14-8-6-12(7-9-14)17-13(10-16(21)22)11-20(19-17)15-4-2-1-3-5-15;/h2*1-9,11H,10H2,(H,21,22);/q;;+2/p-2
InChIKey CAQGVXNKMLYRMF-UHFFFAOYSA-L
SMILES [Ca++].[O-]C(=O)Cc1cn(nc1-c1ccc(Cl)cc1)-c1ccccc1.[O-]C(=O)Cc1cn(nc1-c1ccc(Cl)cc1)-c1ccccc1
Roles Classification
Biological Role(s): EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
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ChEBI Ontology
Outgoing lonazolac calcium (CHEBI:76167) has part lonazolac(1−) (CHEBI:76169)
lonazolac calcium (CHEBI:76167) has role antineoplastic agent (CHEBI:35610)
lonazolac calcium (CHEBI:76167) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
lonazolac calcium (CHEBI:76167) has role non-narcotic analgesic (CHEBI:35481)
lonazolac calcium (CHEBI:76167) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
lonazolac calcium (CHEBI:76167) is a organic calcium salt (CHEBI:51031)
IUPAC Name
calcium bis{[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]acetate}
Synonyms Sources
Lonazolac calcium salt KEGG DRUG
lonazolac-Ca ChEBI
lonazolac.Ca ChEBI
Manual Xrefs Databases
D08142 KEGG DRUG
Lonazolac Wikipedia
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Registry Numbers Types Sources
6472137 Reaxys Registry Number Reaxys
75821-71-5 CAS Registry Number KEGG DRUG
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Last Modified
25 November 2013