CHEBI:143437 - hydroxyethylflurazepam

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This entity has been annotated by a third party. If you would like more information added to this entry, please contact ChEBI via email or GitHub.
ChEBI Name hydroxyethylflurazepam
ChEBI ID CHEBI:143437
Stars This entity has been manually annotated by a third party.
Submitter Mark Williams
Supplier Information
Download Molfile XML SDF
Formula C21H23ClFN3O2
Net Charge 0
Average Mass 403.880
Monoisotopic Mass 403.14628
InChI InChI=1S/C21H23ClFN3O2/c1-2-25(11-12-27)9-10-26-19-8-7-15(22)13-17(19)21(24-14-20(26)28)16-5-3-4-6-18(16)23/h3-8,13,27H,2,9-12,14H2,1H3
InChIKey IRYBKIZHCXMFFO-UHFFFAOYSA-N
SMILES ClC1=CC=2C(=NCC(N(C2C=C1)CCN(CCO)CC)=O)C3=C(F)C=CC=C3
Metabolite of Species Details
Macaca mulatta (NCBI:txid9544 ) See: PubMed
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): human urinary metabolite
Any metabolite (endogenous or exogenous) found in human urine samples.
human xenobiotic metabolite
Any human metabolite produced by metabolism of a xenobiotic compound in humans.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
Application(s): sedative
A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing hydroxyethylflurazepam (CHEBI:143437) has functional parent flurazepam (CHEBI:5128)
hydroxyethylflurazepam (CHEBI:143437) has role human urinary metabolite (CHEBI:84087)
hydroxyethylflurazepam (CHEBI:143437) has role human xenobiotic metabolite (CHEBI:76967)
hydroxyethylflurazepam (CHEBI:143437) has role sedative (CHEBI:35717)
hydroxyethylflurazepam (CHEBI:143437) is a 1,4-benzodiazepinone (CHEBI:35500)
hydroxyethylflurazepam (CHEBI:143437) is a monofluorobenzenes (CHEBI:83575)
hydroxyethylflurazepam (CHEBI:143437) is a organochlorine compound (CHEBI:36683)
hydroxyethylflurazepam (CHEBI:143437) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
7-chloro-1-{2-[ethyl(2-hydroxyethyl)amino]ethyl}-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Registry Number Type Source
67263-28-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
11263563 PubMed citation Europe PMC
11767312 PubMed citation Europe PMC
12545496 PubMed citation Europe PMC
18713517 PubMed citation Europe PMC
1971572 PubMed citation Europe PMC
20077062 PubMed citation Europe PMC
26755538 PubMed citation Europe PMC
27550995 PubMed citation Europe PMC
6427834 PubMed citation Europe PMC
7193008 PubMed citation Europe PMC
7251753 PubMed citation Europe PMC
Last Modified
25 July 2019