CHEBI:50276 - EC 5.99.1.2 (DNA topoisomerase) inhibitor

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ChEBI Name EC 5.99.1.2 (DNA topoisomerase) inhibitor ChEBI ID CHEBI:50276 Definition A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA. Stars This entity has been manually annotated by the ChEBI Team. ChEBI Ontology Outgoing EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) is a topoisomerase inhibitor (CHEBI:70727) Incoming (R)-homocamptothecin (CHEBI:144047) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) (S)-scoulerine (CHEBI:17129) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) amarogentin (CHEBI:2622) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) camptothecin (CHEBI:27656) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) diflomotecan (CHEBI:144046) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) dihydrobetulinic acid (CHEBI:65485) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) disulfiram (CHEBI:4659) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) ellagic acid (CHEBI:4775) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) feruloylagmatine (CHEBI:75544) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) irinotecan (CHEBI:80630) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) irinotecan hydrochloride (anhydrous) (CHEBI:5971) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) irinotecan hydrochloride hydrate (CHEBI:90881) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) kaempferol 3-O-α-L-arabinopyranosyl-7-O-α-L-rhamnopyranoside (CHEBI:68878) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) kaempferol 3-O-β-D-galactopyranosyl-7-O-α-L-rhamnopyranoside (CHEBI:68881) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) kaempferol 3-O-β-D-glucopyranosyl-7-O-α-L-rhamnopyranoside (CHEBI:68882) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) kaempferol 3-O-(5-O-acetyl-α-D-apiofuranosyl)-7-O-α-L-rhamnopyranoside (CHEBI:68877) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) kaempferol 3-O-[α-L-rhamnopyranosyl(1→2)-β-D-galactopyranosyl]-7-O-α-L-rhamnopyranoside (CHEBI:68880) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) kaempferol 3-O-[α-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl]-7-O-α-L-rhamnopyranoside (CHEBI:68879) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) lucanthone (CHEBI:51052) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) manoalide (CHEBI:66666) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) methyl brevifolincarboxylate (CHEBI:66711) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) morin (CHEBI:75092) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) rubitecan (CHEBI:90225) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) saintopin (CHEBI:91276) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) SN-38 (CHEBI:8988) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) topopyrone A (CHEBI:66252) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) topopyrone B (CHEBI:66253) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) topopyrone C (CHEBI:66254) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) topopyrone D (CHEBI:66255) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) topotecan (CHEBI:63632) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) Synonyms Sources DNA topoisomerase inhibitor ChEBI DNA topoisomerase inhibitors ChEBI EC 5.99.1.2 (DNA topoisomerase) inhibitors ChEBI EC 5.99.1.2 (topoisomerase I) inhibitor ChEBI EC 5.99.1.2 (topoisomerase I) inhibitors ChEBI EC 5.99.1.2 inhibitor ChEBI EC 5.99.1.2 inhibitors ChEBI topoisomerase I (EC 5.99.1.2) inhibitor ChEBI topoisomerase I (EC 5.99.1.2) inhibitors ChEBI topoisomerase I inhibitor ChEBI topoisomerase I inhibitors ChEBI type I DNA topoisomerase inhibitor ChEBI type I DNA topoisomerase inhibitors ChEBI Last Modified 03 July 2019