KU-55933 (CHEBI:228209)

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ChEBI Name	KU-55933

ChEBI ID	CHEBI:228209

Definition	A member of the class of thianthrenes that is thianthrene substituted by a 6-(morpholin-4-yl)-4-oxo-4H-pyran-2-yl group at position 1. It is potent inhibitor of ATM kinase.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:91372

Supplier Information

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Formula

C21H17NO3S2

Net Charge

Average Mass

395.490

Monoisotopic Mass

395.06499

InChI

InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2

InChIKey

XRKYMMUGXMWDAO-UHFFFAOYSA-N

SMILES

O=C1C=C(OC(=C1)C1=CC=CC2=C1SC1=C(S2)C=CC=C1)N1CCOCC1

Roles Classification
Biological Role(s):	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. autophagy inducer Any compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).

Application(s):	radiosensitizing agent A drug that makes increases the sensitivity of tumour cells to radiation therapy. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	KU-55933 (CHEBI:228209) has role antineoplastic agent (CHEBI:35610) KU-55933 (CHEBI:228209) has role apoptosis inducer (CHEBI:68495) KU-55933 (CHEBI:228209) has role autophagy inducer (CHEBI:138880) KU-55933 (CHEBI:228209) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925) KU-55933 (CHEBI:228209) has role neuroprotective agent (CHEBI:63726) KU-55933 (CHEBI:228209) has role radiosensitizing agent (CHEBI:132992) KU-55933 (CHEBI:228209) is a 4-pyranones (CHEBI:131906) KU-55933 (CHEBI:228209) is a morpholines (CHEBI:38785) KU-55933 (CHEBI:228209) is a thianthrenes (CHEBI:64513)

IUPAC Name

2-(morpholin-4-yl)-6-(thianthren-1-yl)-4H-pyran-4-one

Synonyms	Sources
2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranone	ChEBI
2-(4-morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one	ChEBI
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	ChEBI
KU 55933	ChEBI
KU55933	ChEBI

Registry Number	Type	Source
587871-26-9	CAS Registry Number	ChEBI

Last Modified

14 November 2023