tirapazamine (CHEBI:78887)

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ChEBI Name	tirapazamine

ChEBI ID	CHEBI:78887

Definition	A member of the class of benzotriazines that is 1,2,4-benzotriazine carrying an amino substituent at position 3 and two oxido substituents at positions 1 and 4.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C7H6N4O2

Net Charge

Average Mass

178.14810

Monoisotopic Mass

178.04908

InChI

InChI=1S/C7H6N4O2/c8-7-9-11(13)6-4-2-1-3-5(6)10(7)12/h1-4H,(H2,8,9)

InChIKey

ORYDPOVDJJZGHQ-UHFFFAOYSA-N

SMILES

Nc1n[n+]([O-])c2ccccc2[n+]1[O-]

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	tirapazamine (CHEBI:78887) has functional parent 1,2,4-benzotriazine (CHEBI:38011) tirapazamine (CHEBI:78887) has role antibacterial agent (CHEBI:33282) tirapazamine (CHEBI:78887) has role antineoplastic agent (CHEBI:35610) tirapazamine (CHEBI:78887) has role apoptosis inducer (CHEBI:68495) tirapazamine (CHEBI:78887) is a N-oxide (CHEBI:35580) tirapazamine (CHEBI:78887) is a aromatic amine (CHEBI:33860) tirapazamine (CHEBI:78887) is a benzotriazines (CHEBI:51361)

IUPAC Name

1,2,4-benzotriazin-3-amine 1,4-dioxide

INN	Source
tirapazamine	KEGG DRUG

Synonyms	Sources
3-Amino-1,2,4-benzotriazine 1,4-dioxide	ChemIDplus
SR 4233	ChemIDplus
SR-4233	ChEBI

Last Modified

18 June 2014