hydrazinocurcumin (CHEBI:84340)

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ChEBI Name	hydrazinocurcumin

ChEBI ID	CHEBI:84340

Definition	A pyrazole obtained by cyclocodensation of the two carbonyl groups of curcumin with hydrazine.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

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Formula

C21H20N2O4

Net Charge

Average Mass

364.39450

Monoisotopic Mass

364.14231

InChI

InChI=1S/C21H20N2O4/c1-26-20-11-14(5-9-18(20)24)3-7-16-13-17(23-22-16)8-4-15-6-10-19(25)21(12-15)27-2/h3-13,24-25H,1-2H3,(H,22,23)/b7-3+,8-4+

InChIKey

LKLASFRCXLTNMY-FCXRPNKRSA-N

SMILES

COc1cc(\C=C\c2cc(\C=C\c3ccc(O)c(OC)c3)[nH]n2)ccc1O

Roles Classification
Biological Role(s):	EC 2.3.1.48 (histone acetyltransferase) inhibitor An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the function of histone acetyltransferase (EC 2.3.1.48). EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.

Application(s):	angiogenesis modulating agent An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	hydrazinocurcumin (CHEBI:84340) has functional parent curcumin (CHEBI:3962) hydrazinocurcumin (CHEBI:84340) has role angiogenesis modulating agent (CHEBI:50926) hydrazinocurcumin (CHEBI:84340) has role antineoplastic agent (CHEBI:35610) hydrazinocurcumin (CHEBI:84340) has role EC 2.3.1.48 (histone acetyltransferase) inhibitor (CHEBI:76395) hydrazinocurcumin (CHEBI:84340) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925) hydrazinocurcumin (CHEBI:84340) is a aromatic ether (CHEBI:35618) hydrazinocurcumin (CHEBI:84340) is a olefinic compound (CHEBI:78840) hydrazinocurcumin (CHEBI:84340) is a polyphenol (CHEBI:26195) hydrazinocurcumin (CHEBI:84340) is a pyrazoles (CHEBI:26410)

IUPAC Name

4,4'-[1H-pyrazole-3,5-diyldi(E)ethene-2,1-diyl]bis(2-methoxyphenol)

Synonym	Source
pyrazole-curcumin	ChEBI

Registry Number	Type	Source
4271395	Reaxys Registry Number	Reaxys

Last Modified

16 January 2015