CHEBI:76138 - flunixin

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name flunixin
ChEBI ID CHEBI:76138
Definition A pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a 2-methyl-3-(trifluoromethyl)phenylamino group. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine (usually as the meglumine salt) for treatment of horses, cattle and pigs.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C14H11F3N2O2
Net Charge 0
Average Mass 296.24450
Monoisotopic Mass 296.07726
InChI InChI=1S/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21)
InChIKey NOOCSNJCXJYGPE-UHFFFAOYSA-N
SMILES Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
Application(s): non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
antipyretic
A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing flunixin (CHEBI:76138) has functional parent nicotinic acid (CHEBI:15940)
flunixin (CHEBI:76138) has role antipyretic (CHEBI:35493)
flunixin (CHEBI:76138) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
flunixin (CHEBI:76138) has role non-narcotic analgesic (CHEBI:35481)
flunixin (CHEBI:76138) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
flunixin (CHEBI:76138) is a aminopyridine (CHEBI:38207)
flunixin (CHEBI:76138) is a organofluorine compound (CHEBI:37143)
flunixin (CHEBI:76138) is a pyridinemonocarboxylic acid (CHEBI:26420)
flunixin (CHEBI:76138) is conjugate acid of flunixin(1−) (CHEBI:76153)
Incoming flunixin(1−) (CHEBI:76153) is conjugate base of flunixin (CHEBI:76138)
IUPAC Name
2-{[2-methyl-3-(trifluoromethyl)phenyl]amino}nicotinic acid
INNs Sources
flunixin KEGG DRUG
flunixine ChemIDplus
flunixino ChemIDplus
flunixinum ChemIDplus
Synonyms Sources
2-((2-methyl-3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxylic acid ChemIDplus
2-333-trifluoro-2,3-xylidino)nicotinic acid ChemIDplus
Sch 14714 ChemIDplus
Manual Xrefs Databases
1802 VSDB
D04215 KEGG DRUG
Flunixin Wikipedia
US2008014272 Patent
US5637617 Patent
View more database links
Registry Numbers Types Sources
38677-85-9 CAS Registry Number KEGG DRUG
38677-85-9 CAS Registry Number ChemIDplus
492802 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
26512724 PubMed citation Europe PMC
26695354 PubMed citation Europe PMC
27242945 PubMed citation Europe PMC
27731498 PubMed citation Europe PMC
27958751 PubMed citation Europe PMC
2816 PubMed citation Europe PMC
Last Modified
15 June 2017