3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol (CHEBI:64060)

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ChEBI Name	3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol

ChEBI ID	CHEBI:64060

Definition	An N-alkylpiperazine that is 1-(3-chlorophenyl)piperazine carrying a 3,3-diphenyl-2-hydroxyprop-1-yl group at position 4. A selective h5-HT_1D antagonist, displaying 60-fold selectivity over h5-HT_1B, and exhibiting little or no affinity for a range of other receptor types.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

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Formula

C25H27ClN2O

Net Charge

Average Mass

406.94800

Monoisotopic Mass

406.18119

InChI

InChI=1S/C25H27ClN2O/c26-22-12-7-13-23(18-22)28-16-14-27(15-17-28)19-24(29)25(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-13,18,24-25,29H,14-17,19H2

InChIKey

QJHCTHPYUOXOGM-UHFFFAOYSA-N

SMILES

OC(CN1CCN(CC1)c1cccc(Cl)c1)C(c1ccccc1)c1ccccc1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

Application(s):	geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

ChEBI Ontology
Outgoing	3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol (CHEBI:64060) has role geroprotector (CHEBI:176497) 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol (CHEBI:64060) has role serotonergic antagonist (CHEBI:48279) 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol (CHEBI:64060) is a N-alkylpiperazine (CHEBI:46845) 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol (CHEBI:64060) is a N-arylpiperazine (CHEBI:46848) 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol (CHEBI:64060) is a monochlorobenzenes (CHEBI:83403) 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol (CHEBI:64060) is a secondary alcohol (CHEBI:35681) 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol (CHEBI:64060) is conjugate base of 4-(3-chlorophenyl)-1-(2-hydroxy-3,3-diphenylpropyl)piperazin-1-ium(1+) (CHEBI:64059)

Incoming	4-(3-chlorophenyl)-1-(2-hydroxy-3,3-diphenylpropyl)piperazin-1-ium(1+) (CHEBI:64059) is conjugate acid of 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol (CHEBI:64060)

IUPAC Name

3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol

Synonyms	Sources
1-(diphenylmethyl)-2-(4-(3-chlorophenyl)-1-piperazinyl)ethanol	ChemIDplus
3-(4-(3-chlorophenyl)-1-piperazinyl)-1,1-diphenyl-2-propanol	ChemIDplus
3-(4-(3-chlorophenyl)piperazin-1-yl)-1,1,-diphenyl-2-propanol	ChemIDplus
BRL 15572	ChEBI
BRL-15,572	ChemIDplus
BRL-15572	ChemIDplus
BRL15572	ChEBI

Last Modified

21 September 2021