CHEBI:83807 - paliperidone palmitate

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ChEBI Name paliperidone palmitate
ChEBI ID CHEBI:83807
Definition A racemate comprising equimolar amounts of (R)- and (S)-paliperidone palmitate. A long-acting injectable formulation of paliperidone (the major active metabolite of risperidone) that is used for treatment of schizophrenia.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C39H57FN4O4
Net Charge 0
Average Mass 664.89270
Monoisotopic Mass 664.43638
Roles Classification
Biological Role(s): alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Application(s): alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
psychotropic drug
A loosely defined grouping of drugs that have effects on psychological function.
second generation antipsychotic
Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing paliperidone palmitate (CHEBI:83807) has part (R)-paliperidone palmitate (CHEBI:83810)
paliperidone palmitate (CHEBI:83807) has part (S)-paliperidone palmitate (CHEBI:83809)
paliperidone palmitate (CHEBI:83807) has role α-adrenergic antagonist (CHEBI:37890)
paliperidone palmitate (CHEBI:83807) has role dopaminergic antagonist (CHEBI:48561)
paliperidone palmitate (CHEBI:83807) has role H1-receptor antagonist (CHEBI:37955)
paliperidone palmitate (CHEBI:83807) has role neuroprotective agent (CHEBI:63726)
paliperidone palmitate (CHEBI:83807) has role psychotropic drug (CHEBI:35471)
paliperidone palmitate (CHEBI:83807) has role second generation antipsychotic (CHEBI:65191)
paliperidone palmitate (CHEBI:83807) has role serotonergic antagonist (CHEBI:48279)
paliperidone palmitate (CHEBI:83807) is a racemate (CHEBI:60911)
IUPAC Name
rac-3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl hexadecanoate
Synonyms Sources
(±)-paliperidone palmitate ChEBI
(RS)-paliperidone palmitate ChEBI
paliperidone hexadecanoate ChEBI
rac-paliperidone palmitate ChEBI
racemic paliperidone palmitate ChEBI
RO 92670 ChemIDplus
RO92670 ChemIDplus
Brand Names Sources
INVEGA SUSTENNA KEGG DRUG
Xeplion KEGG DRUG
Manual Xrefs Databases
D05340 KEGG DRUG
Paliperidone Wikipedia
View more database links
Registry Numbers Types Sources
15026585 Reaxys Registry Number Reaxys
199739-10-1 CAS Registry Number ChemIDplus
199739-10-1 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
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Last Modified
22 February 2017