3-hydroxyglutaric acid (CHEBI:39980)

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ChEBI Name	3-hydroxyglutaric acid

ChEBI ID	CHEBI:39980

Definition	A 3 hydroxy carboxylic acid that is glutaric acid which is substituted by a hydroxy group at position 3. It is a diagnostic marker for glutaric aciduria type I.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

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Formula

C5H8O5

Net Charge

Average Mass

148.114

Monoisotopic Mass

148.03717

InChI

InChI=1S/C5H8O5/c6-3(1-4(7)8)2-5(9)10/h3,6H,1-2H2,(H,7,8)(H,9,10)

InChIKey

ZQHYXNSQOIDNTL-UHFFFAOYSA-N

SMILES

C(CC(CC(=O)O)O)(=O)O

Metabolite of Species	Details
Homo sapiens (NCBI:txid9606)	Found in blood (UBERON:0000178). See: PubMed
Homo sapiens (NCBI:txid9606)	Found in cerebrospinal fluid (UBERON:0001359). See: PubMed
Homo sapiens (NCBI:txid9606)	Found in blood plasma (BTO_0000131). See: PubMed
Homo sapiens (NCBI:txid9606)	Found in urine (BTO:0001419). See: PubMed

Roles Classification
Chemical Role(s):	Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). (via oxoacid )

Biological Role(s):	human urinary metabolite Any metabolite (endogenous or exogenous) found in human urine samples. human blood serum metabolite Any metabolite (endogenous or exogenous) found in human blood serum samples.

ChEBI Ontology
Outgoing	3-hydroxyglutaric acid (CHEBI:39980) has functional parent glutaric acid (CHEBI:17859) 3-hydroxyglutaric acid (CHEBI:39980) has role human blood serum metabolite (CHEBI:85234) 3-hydroxyglutaric acid (CHEBI:39980) has role human urinary metabolite (CHEBI:84087) 3-hydroxyglutaric acid (CHEBI:39980) is a α,ω-dicarboxylic acid (CHEBI:28383) 3-hydroxyglutaric acid (CHEBI:39980) is a 3-hydroxy carboxylic acid (CHEBI:61355) 3-hydroxyglutaric acid (CHEBI:39980) is conjugate acid of 3-hydroxyglutarate(2−) (CHEBI:191379)

Incoming	3-hydroxyglutarate(2−) (CHEBI:191379) is conjugate base of 3-hydroxyglutaric acid (CHEBI:39980)

IUPAC Name

3-hydroxypentanedioic acid

Last Modified

09 May 2022