InChI=1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)/t42-,43+,44+,46-,47-,48-,49+,50-/m0/s1 |
VQFKFAKEUMHBLV-BYSUZVQFSA-N |
CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@H](O)CCCCCCCCCCCCCC |
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immunological adjuvant
A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity.
antigen
Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC).
epitope
The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.
allergen
A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.
mouse metabolite
Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
(via N-acylphytosphingosine )
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immunological adjuvant
A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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View more via ChEBI Ontology
Outgoing
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1-O-(α-D-galactosyl)-N-hexacosanoylphytosphingosine
(CHEBI:466659)
has functional parent
α-D-galactose
(CHEBI:28061)
1-O-(α-D-galactosyl)-N-hexacosanoylphytosphingosine
(CHEBI:466659)
has role
allergen
(CHEBI:50904)
1-O-(α-D-galactosyl)-N-hexacosanoylphytosphingosine
(CHEBI:466659)
has role
antigen
(CHEBI:59132)
1-O-(α-D-galactosyl)-N-hexacosanoylphytosphingosine
(CHEBI:466659)
has role
antineoplastic agent
(CHEBI:35610)
1-O-(α-D-galactosyl)-N-hexacosanoylphytosphingosine
(CHEBI:466659)
has role
epitope
(CHEBI:53000)
1-O-(α-D-galactosyl)-N-hexacosanoylphytosphingosine
(CHEBI:466659)
has role
immunological adjuvant
(CHEBI:50847)
1-O-(α-D-galactosyl)-N-hexacosanoylphytosphingosine
(CHEBI:466659)
is a
N-acyl-β-D-galactosylphytosphingosine
(CHEBI:157775)
1-O-(α-D-galactosyl)-N-hexacosanoylphytosphingosine
(CHEBI:466659)
is a
glycophytoceramide
(CHEBI:59389)
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Incoming
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N-[(2S,3S,4R)-1-(α-D-galactosyloxy)-3,4-dihydroxyoctadecan-2-yl]hexacosanethioamide
(CHEBI:86510)
has functional parent
1-O-(α-D-galactosyl)-N-hexacosanoylphytosphingosine
(CHEBI:466659)
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N-[(2S,3S,4R)-1-(α-D-galactopyranosyloxy)-3,4-dihydroxyoctadecan-2-yl]hexacosanamide
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(2S,3S,4R)-1-O-(α-D-galactosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol
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ChEBI
|
1-O-(α-D-galactopyranosyl)-N-hexacosanoylphytosphingosine
|
ChEBI
|
α-GalCer
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ChEBI
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α-GalCer(t18:0/26:0)
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ChEBI
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α-GC (C26)
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ChEBI
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α-GC(C26)
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ChEBI
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Galα-Cer(t18:0/26:0)
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ChEBI
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KRN 7000
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ChemIDplus
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158021-47-7
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CAS Registry Number
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ChemIDplus
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7326597
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Reaxys Registry Number
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Reaxys
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7326597
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Beilstein Registry Number
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Beilstein
|
11914907
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PubMed citation
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Europe PMC
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12473579
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PubMed citation
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Europe PMC
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15246159
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PubMed citation
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Europe PMC
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16007090
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PubMed citation
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Europe PMC
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16458002
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PubMed citation
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Europe PMC
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17431340
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PubMed citation
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Europe PMC
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17581592
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PubMed citation
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Europe PMC
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18418814
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PubMed citation
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Europe PMC
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18586489
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PubMed citation
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Europe PMC
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19502056
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PubMed citation
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Europe PMC
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20080535
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PubMed citation
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Europe PMC
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20616071
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PubMed citation
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Europe PMC
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21376639
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PubMed citation
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Europe PMC
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21394364
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PubMed citation
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Europe PMC
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29351991
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PubMed citation
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Europe PMC
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31827147
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PubMed citation
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Europe PMC
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8866665
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PubMed citation
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Europe PMC
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