hydroxyzine (CHEBI:5818)

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ChEBI Name	hydroxyzine

ChEBI ID	CHEBI:5818

Definition	A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C21H27ClN2O2

Net Charge

Average Mass

374.90406

Monoisotopic Mass

374.17611

InChI

InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2

InChIKey

ZQDWXGKKHFNSQK-UHFFFAOYSA-N

SMILES

OCCOCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses.

Application(s):	H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. antipruritic drug A drug, usually applied topically, that relieves pruritus (itching).

ChEBI Ontology
Outgoing	hydroxyzine (CHEBI:5818) has role anticoronaviral agent (CHEBI:149553) hydroxyzine (CHEBI:5818) has role antipruritic drug (CHEBI:59683) hydroxyzine (CHEBI:5818) has role anxiolytic drug (CHEBI:35474) hydroxyzine (CHEBI:5818) has role dermatologic drug (CHEBI:50177) hydroxyzine (CHEBI:5818) has role H₁-receptor antagonist (CHEBI:37955) hydroxyzine (CHEBI:5818) is a N-alkylpiperazine (CHEBI:46845) hydroxyzine (CHEBI:5818) is a hydroxyether (CHEBI:46789) hydroxyzine (CHEBI:5818) is a monochlorobenzenes (CHEBI:83403)

Incoming	hydroxyzine hydrochloride (CHEBI:5819) has part hydroxyzine (CHEBI:5818) hydroxyzine pamoate (CHEBI:31680) has part hydroxyzine (CHEBI:5818)

IUPAC Name

2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol

Last Modified

23 April 2020