CHEBI:65824 - EI-1625-2

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ChEBI Name EI-1625-2
ChEBI ID CHEBI:65824
Definition An epoxide isolated from Streptomyces sp. E-1625. An inhibitor of interleukin-1β converting enzyme (ICE), it acts as an anti-inflammatory agent and antibiotic.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C27H32N2O7
Net Charge 0
Average Mass 496.55220
Monoisotopic Mass 496.22095
InChI InChI=1S/C27H32N2O7/c1-3-4-9-17(2)11-14-22(33)28-18-16-27(35,26-25(36-26)24(18)34)15-8-6-5-7-10-21(32)29-23-19(30)12-13-20(23)31/h5-8,10-11,14-17,25-26,30,35H,3-4,9,12-13H2,1-2H3,(H,28,33)(H,29,32)/b6-5+,10-7+,14-11+,15-8+/t17?,25-,26-,27-/m1/s1
InChIKey LEERCZRUWSNMMK-GIWWSJOHSA-N
SMILES [H][C@]12O[C@@]1([H])[C@](O)(C=C(NC(=O)\C=C\C(C)CCCC)C2=O)\C=C\C=C\C=C\C(=O)NC1=C(O)CCC1=O
Metabolite of Species Details
Streptomyces sp. (NCBI:txid1931) of strain E 1625 See: PubMed
Roles Classification
Biological Role(s): antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
bacterial metabolite
Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
EC 3.4.22.36 (caspase-1) inhibitor
Any EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the activity of caspase-1 (EC 3.4.22.36).
Application(s): anti-inflammatory agent
Any compound that has anti-inflammatory effects.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing EI-1625-2 (CHEBI:65824) has role anti-inflammatory agent (CHEBI:67079)
EI-1625-2 (CHEBI:65824) has role antimicrobial agent (CHEBI:33281)
EI-1625-2 (CHEBI:65824) has role bacterial metabolite (CHEBI:76969)
EI-1625-2 (CHEBI:65824) has role EC 3.4.22.36 (caspase-1) inhibitor (CHEBI:76795)
EI-1625-2 (CHEBI:65824) is a cyclic ketone (CHEBI:3992)
EI-1625-2 (CHEBI:65824) is a enol (CHEBI:33823)
EI-1625-2 (CHEBI:65824) is a epoxide (CHEBI:32955)
EI-1625-2 (CHEBI:65824) is a monocarboxylic acid amide (CHEBI:29347)
EI-1625-2 (CHEBI:65824) is a tertiary alcohol (CHEBI:26878)
IUPAC Name
(2E)-N-[(1S,5R,6R)-5-hydroxy-5-{(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopent-1-en-1-yl)amino]-7-oxohepta-1,3,5-trien-1-yl}-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-4-methyloct-2-enamide
Registry Number Type Source
7630442 Reaxys Registry Number Reaxys
Citation Waiting for Citations Type Source
8982334 PubMed citation Europe PMC
Last Modified
05 March 2014