trichostatin A (CHEBI:46024)

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ChEBI Name	trichostatin A

ChEBI ID	CHEBI:46024

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:39145, CHEBI:46022

Supplier Information

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Formula

C17H22N2O3

Net Charge

Average Mass

302.36826

Monoisotopic Mass

302.16304

InChI

InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1

InChIKey

RTKIYFITIVXBLE-QEQCGCAPSA-N

SMILES

C[C@@H](C(=O)c1ccc(cc1)N(C)C)\C=C(C)\C=C\C(=O)NO

Metabolite of Species	Details
Streptomyces hygroscopicus (NCBI:txid1912)	See: PubMed

Roles Classification
Biological Role(s):	bacterial metabolite Any prokaryotic metabolite produced during a metabolic reaction in bacteria. EC 3.5.1.98 (histone deacetylase) inhibitor An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98). antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. (via antibiotic antifungal agent ) antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. (via carbocyclic antibiotic )

Application(s):	geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.

ChEBI Ontology
Outgoing	trichostatin A (CHEBI:46024) has functional parent (R)-trichostatic acid (CHEBI:39158) trichostatin A (CHEBI:46024) has role bacterial metabolite (CHEBI:76969) trichostatin A (CHEBI:46024) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115) trichostatin A (CHEBI:46024) has role geroprotector (CHEBI:176497) trichostatin A (CHEBI:46024) is a antibiotic antifungal agent (CHEBI:86478) trichostatin A (CHEBI:46024) is a hydroxamic acid (CHEBI:24650) trichostatin A (CHEBI:46024) is a trichostatin (CHEBI:39146)

Incoming	trichostatin C (CHEBI:39147) has functional parent trichostatin A (CHEBI:46024) trichostatin D (CHEBI:39160) has functional parent trichostatin A (CHEBI:46024)

IUPAC Name

(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide

Synonyms	Sources
(2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide	ChemIDplus
TRICHOSTATIN A	PDBeChem
TSA	ChemIDplus

Last Modified

27 October 2021