ethylisopropylamiloride (CHEBI:136538)

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ChEBI Name	ethylisopropylamiloride

ChEBI ID	CHEBI:136538

Definition	A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C11H18ClN7O

Net Charge

Average Mass

299.760

Monoisotopic Mass

299.12614

InChI

InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)

InChIKey

QDERNBXNXJCIQK-UHFFFAOYSA-N

SMILES

C=1(C(=NC(=C(N1)Cl)N(C(C)C)CC)N)C(NC(N)=N)=O

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	sodium channel blocker An agent that inhibits sodium influx through cell membranes.

Application(s):	anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders.

ChEBI Ontology
Outgoing	ethylisopropylamiloride (CHEBI:136538) has functional parent amiloride (CHEBI:2639) ethylisopropylamiloride (CHEBI:136538) has role anti-arrhythmia drug (CHEBI:38070) ethylisopropylamiloride (CHEBI:136538) has role neuroprotective agent (CHEBI:63726) ethylisopropylamiloride (CHEBI:136538) has role sodium channel blocker (CHEBI:38633) ethylisopropylamiloride (CHEBI:136538) is a aromatic amine (CHEBI:33860) ethylisopropylamiloride (CHEBI:136538) is a guanidines (CHEBI:24436) ethylisopropylamiloride (CHEBI:136538) is a monocarboxylic acid amide (CHEBI:29347) ethylisopropylamiloride (CHEBI:136538) is a organochlorine compound (CHEBI:36683) ethylisopropylamiloride (CHEBI:136538) is a pyrazines (CHEBI:38314) ethylisopropylamiloride (CHEBI:136538) is a tertiary amino compound (CHEBI:50996)

IUPAC Name

3-amino-N-carbamimidoyl-6-chloro-5-[ethyl(isopropyl)amino]pyrazine-2-carboxamide

Synonyms	Sources
3-amino-N-(aminoiminomethyl)-6-chloro-5-(ethyl(1-methylethyl)amino)pyrazinecarboxamide	ChemIDplus
5-(ethylisopropyl)amiloride	ChemIDplus
5-(N-ethyl-N-isopropyl)amiloride	ChemIDplus
EIPA	ChemIDplus
ethyl isopropyl amiloride	ChemIDplus
N-amidino-3-amino-5-ethylisopropylamino-6-chloropyrazine carboxamide	ChemIDplus

Registry Number	Type	Source
1154-25-2	CAS Registry Number	ChemIDplus

Last Modified

13 March 2017