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CHEBI:65823 - EI-1511-5
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ChEBI Name
EI-1511-5
ChEBI ID
CHEBI:65823
Definition
An epoxide isolated from
Streptomyces
sp. E-1511. An inhibitor of interleukin-1β converting enzyme (ICE), it acts as an anti-inflammatory agent and an antibiotic.
Stars
This entity has been manually annotated by the ChEBI Team.
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Formula
C29H32N2O7
Net Charge
0
Average Mass
520.57360
Monoisotopic Mass
520.22095
InChI
InChI=1S/C29H32N2O7/c1-
3-
19(2)
12-
8-
4-
5-
9-
13-
23(34)
30-
20-
18-
29(37,28-
27(38-
28)
26(20)
36)
17-
11-
7-
6-
10-
14-
24(35)
31-
25-
21(32)
15-
16-
22(25)
33/h4-
14,17-
19,27-
28,32,37H,3,15-
16H2,1-
2H3,(H,30,34)
(H,31,35)
/b5-
4+,7-
6+,12-
8+,13-
9+,14-
10+,17-
11+/t19?,27-
,28-
,29+/m1/s1
InChIKey
OTILGUINRVYYKM-BSZZVILASA-N
SMILES
[H][C@]12O[C@@]1([H])[C@](O)(\C=C\C=C\C=C\C(=O)NC1=C(O)CCC1=O)C=C(NC(=O)\C=C\C=C\C=C\C(C)CC)C2=O
Metabolite of Species
Details
Streptomyces
sp.
(NCBI:txid1931)
of strain E 1511 See:
PubMed
Roles Classification
Biological Role
(s):
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
EC 3.4.22.36 (caspase-1) inhibitor
Any EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the activity of caspase-1 (EC 3.4.22.36).
bacterial metabolite
Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
Application
(s):
anti-inflammatory agent
Any compound that has anti-inflammatory effects.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
EI-1511-5 (
CHEBI:65823
)
has role
anti-inflammatory agent (
CHEBI:67079
)
EI-1511-5 (
CHEBI:65823
)
has role
antimicrobial agent (
CHEBI:33281
)
EI-1511-5 (
CHEBI:65823
)
has role
bacterial metabolite (
CHEBI:76969
)
EI-1511-5 (
CHEBI:65823
)
has role
EC 3.4.22.36 (caspase-1) inhibitor (
CHEBI:76795
)
EI-1511-5 (
CHEBI:65823
)
is a
cyclic ketone (
CHEBI:3992
)
EI-1511-5 (
CHEBI:65823
)
is a
enol (
CHEBI:33823
)
EI-1511-5 (
CHEBI:65823
)
is a
epoxide (
CHEBI:32955
)
EI-1511-5 (
CHEBI:65823
)
is a
monocarboxylic acid amide (
CHEBI:29347
)
EI-1511-5 (
CHEBI:65823
)
is a
tertiary alcohol (
CHEBI:26878
)
IUPAC Name
(2
E
,4
E
,6
E
)-
N
-
[(1
S
,5
S
,6
R
)-
5-
hydroxy-
5-
{(1
E
,3
E
,5
E
)-
7-
[(2-
hydroxy-
5-
oxocyclopent-
1-
en-
1-
yl)amino]-
7-
oxohepta-
1,3,5-
trien-
1-
yl}-
2-
oxo-
7-
oxabicyclo[4.1.0]hept-
3-
en-
3-
yl]-
8-
methyldeca-
2,4,6-
trienamide
Registry Number
Type
Source
7630198
Reaxys Registry Number
Reaxys
Citation
Type
Source
8982334
PubMed citation
Europe PMC
Last Modified
01 May 2014