3',4'-dihydroxyaurone (CHEBI:144745)

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ChEBI Name	3',4'-dihydroxyaurone

ChEBI ID	CHEBI:144745

Definition	A hydroxyaurone that is aurone which is substituted by hydroxy groups at the 3' and 4' positions; major species at pH 7.3. It shows inhibitory activity against several isoforms of the histone deacetylase complex (HDAC).

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Anne Morgat

Supplier Information

Download	Molfile XML SDF

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Formula

C15H10O4

Net Charge

Average Mass

254.241

Monoisotopic Mass

254.05791

InChI

InChI=1S/C15H10O4/c16-11-6-5-9(7-12(11)17)8-14-15(18)10-3-1-2-4-13(10)19-14/h1-8,16-17H/b14-8-

InChIKey

HCBULGQMULJTCM-ZSOIEALJSA-N

SMILES

C1=CC=CC2=C1C(=O)/C(=C/C3=CC=C(C(=C3)O)O)/O2

Roles Classification
Biological Role(s):	EC 3.5.1.98 (histone deacetylase) inhibitor An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).

ChEBI Ontology
Outgoing	3',4'-dihydroxyaurone (CHEBI:144745) has functional parent 2',3,4-trihydroxy-trans-chalcone (CHEBI:144742) 3',4'-dihydroxyaurone (CHEBI:144745) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115) 3',4'-dihydroxyaurone (CHEBI:144745) is a catechols (CHEBI:33566) 3',4'-dihydroxyaurone (CHEBI:144745) is a hydroxyaurone (CHEBI:85970)

IUPAC Name

(2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-1-benzofuran-3(2H)-one

Synonym	Source
3',4'-dihydroxyaurone	UniProt

Last Modified

05 September 2019