duvoglustat (CHEBI:44369)

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ChEBI Name	duvoglustat

ChEBI ID	CHEBI:44369

Definition	An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	qingping liu qingping liu

Secondary ChEBI IDs	CHEBI:132398, CHEBI:76525, CHEBI:132867

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Formula

C6H13NO4

Net Charge

Average Mass

163.17170

Monoisotopic Mass

163.08446

InChI

InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1

InChIKey

LXBIFEVIBLOUGU-JGWLITMVSA-N

SMILES

OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O

Metabolite of Species	Details
Bacillus amyloliquefaciens (NCBI:txid1390)	See: PubMed
Bacillus subtilis (NCBI:txid1423)	See: PubMed
Moraceae (NCBI:txid3487)	See: PubMed
Morus alba (NCBI:txid3498)	Found in latex (BTO:0000710). See: PubMed

Roles Classification
Biological Role(s):	EC 3.2.1.20 (alpha-glucosidase) inhibitor An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of alpha-glucosidase (EC 3.2.1.20). anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. anti-obesity agent Any substance which is used to reduce or control weight. bacterial metabolite Any prokaryotic metabolite produced during a metabolic reaction in bacteria. plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. (via alkaloid )

Application(s):	hypoglycemic agent A drug which lowers the blood glucose level. hepatoprotective agent Any compound that is able to prevent damage to the liver.

ChEBI Ontology
Outgoing	duvoglustat (CHEBI:44369) has role anti-HIV agent (CHEBI:64946) duvoglustat (CHEBI:44369) has role anti-obesity agent (CHEBI:74518) duvoglustat (CHEBI:44369) has role bacterial metabolite (CHEBI:76969) duvoglustat (CHEBI:44369) has role EC 3.2.1.20 (α-glucosidase) inhibitor (CHEBI:67239) duvoglustat (CHEBI:44369) has role hepatoprotective agent (CHEBI:62868) duvoglustat (CHEBI:44369) has role hypoglycemic agent (CHEBI:35526) duvoglustat (CHEBI:44369) has role plant metabolite (CHEBI:76924) duvoglustat (CHEBI:44369) is a 2-(hydroxymethyl)piperidine-3,4,5-triol (CHEBI:72490) duvoglustat (CHEBI:44369) is a piperidine alkaloid (CHEBI:26147)

Incoming	1-deoxynojirimycin-1-sulfonic acid (CHEBI:167649) has functional parent duvoglustat (CHEBI:44369) 4-O-α-D-glucopyranosylmoranoline (CHEBI:70736) has functional parent duvoglustat (CHEBI:44369) N-ethyl-1-deoxynojirimycin (CHEBI:167666) has functional parent duvoglustat (CHEBI:44369) N-methyl-1-deoxynojirimycin (CHEBI:166564) has functional parent duvoglustat (CHEBI:44369) N-nonyldeoxynojirimycin (CHEBI:76399) has functional parent duvoglustat (CHEBI:44369) miglustat (CHEBI:50381) has functional parent duvoglustat (CHEBI:44369)

IUPAC Name

(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol

INN	Source
duvoglustat	KEGG DRUG

Synonyms	Sources
(+)-1-Deoxynojirimycin	KNApSAcK
1,5-deoxy-1,5-imino-D-mannitol	DrugBank
1,5-dideoxy-1,5-imino-D-glucitol	DrugBank
1-Deoxymannojirimycin	DrugBank
1-Deoxynojirimycin	KEGG DRUG
1-DEOXYNOJIRIMYCIN	PDBeChem
5-amino-1,5-dideoxy-D-glucopyranose	DrugBank
BAY-H-5595	DrugBank
D-1-deoxynojirimycin	DrugBank
DNJ	DrugBank
Moranolin	KEGG COMPOUND
Moranoline	ChemIDplus

Last Modified

13 April 2021